Publications by authors named "Selene Francesca Anna Drago"
The discovery of serine protease proprotein convertase subtilisin-kexin type 9 (PCSK9) has revolutionized pharmacological lipid-lowering treatments. The first PCSK9 antagonists (PCSK9-A), evolocumab and alirocumab, were approved in 2015. Targeting PCSK9 synthesis marked a major advancement in this field, leading to the development of inclisiran, a long-acting siRNA targeting PCSK9 mRNA.
View Article and Find Full Text PDFEffects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study.
Selene Francesca Anna Drago Michelangelo Rottura Antonino Molonia Viviana Maria Gianguzzo Giovanni Pallio
Pharmaceuticals (Basel)
June 2024
Article Synopsis
- Chronic venous insufficiency (CVI) can increase the risk of cardiovascular events, and its primary treatments are compression stockings and lifestyle changes, potentially supported by natural products like flavonoids.
- This study evaluated the effects of a dietary supplement containing baicalin, bromelain, and escin in CVI patients through a retrospective analysis of medical records.
- Results showed significant improvements in the clinical symptoms of "users" of the supplement compared to "non-users," including reduced pain, inflammation, and overall severity of CVI, along with lower C-reactive Protein levels.
Article Synopsis
- The study aimed to analyze changes in glomerular filtration ratio (GFR) among diabetic patients and identify related risk factors under the care of General Practitioners (GPs).
- Researchers recruited 545 diabetic patients, estimated their GFR based on creatinine values, and used linear regression to determine predictors of eGFR changes.
- Findings revealed that most patients were on glucose-lowering medications, often had prescriptions for nephrotoxic drugs, and highlighted the need for closer monitoring of diabetic patients' kidney health, irrespective of their current GFR levels.
Article Synopsis
- - Regulated cell death (RCD), specifically apoptosis, plays a critical role in enhancing herpes simplex virus-1 (HSV-1) replication and release, influenced by the type of cells and the host species involved.
- - The study reveals that caspase-8 is essential for HSV-1-induced apoptosis, acting independently of traditional death receptors in both mouse embryo fibroblasts and human monocytes, with caspase-8-deficient cells showing impaired apoptosis and viral release.
- - Caspase-8-deficient cells exhibit increased autophagy, which prevents effective viral release; however, inhibiting autophagy enables these cells to release viral particles similar to normal cells, indicating a complex role for casp
Article Synopsis
- - Multiple acyl-CoA dehydrogenase deficiency (MADD) is a genetic disorder that affects fatty acid metabolism, leading to symptoms like muscle weakness and exercise intolerance; riboflavin supplementation has shown to improve patient outcomes.
- - A retrospective study analyzed 10 unrelated patients diagnosed with MADD over 20 years, using clinical evaluations, blood tests, muscle biopsies, and genetic analysis to assess their condition.
- - Common clinical symptoms included fatigue, difficulty chewing, and increased serum CK and LDH levels, with genetic analysis revealing 14 pathogenic variants; all patients improved with riboflavin treatment.