The effects of glipizide on DNA damage and nuclear transport in differentiated 3T3-L1 adipocytes.

Background: Despite commonly use for treatment of type II diabetes, possible effects of glipizide on nuclear transport and DNA damage in cells are unknown. Since clinical response of glipizide may change with aging, the aim of the study was to investigate the effect of glipizide by comparing mature and senescent adipocytes.

Methods And Results: The effects of glipizide were investigated in 3T3-L1 adipocytes.

DNA Damage in AML-12 Hepatocytes and 3T3-L1 Adipocytes Treated with Clopidogrel.

Background: Clopidogrel has been commonly prescribed as a selective P2Y12 receptor antagonist to reduce heart attack and stroke risk. Nearly 10% of absorbed clopidogrel is metabolized to active forms by cytochrome P450 (CYP) enzymes in the liver and 90% to inactive clopidogrel carboxylate by esterases.

Objective: Since different forms of clopidogrel have cytotoxic potential, our aim was to determine the effect of 7.