Publications by authors named "Selcuk Balci"
Introduction: Advances in neonatal and pediatric intensive care have improved patient survival rates, emphasizing the need for respiratory support in cases of chronic respiratory failure, resulting in the establishment of the Turkish National Pediatric Patients Receiving Home Mechanical Ventilation (HMV) Support Registration System in 2023. This study aims to present the initial findings of the registry.
Methods: In this cross-sectional study, epidemiological and demographic data was obtained from the registry and compared between invasive ventilation (IV) and non-invasive ventilation (NIV) groups.
Background: Our study aimed to identify the social domains that pose the greatest barriers to managing and supporting pwCF, particularly in relation to income levels.
Methods: To identify associations between income and health outcomes in pwCF in our center the shorter form of the survey "Your Current Life Situation" (YCLS) was used in face-to-face interviews. Participants were also asked to complete the validated Turkish versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) to assess depression and anxiety, respectively.
Introduction: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF.
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- Genetic variants in the CFTR gene cause cystic fibrosis (CF), and this study explores the genotypic and phenotypic diversity of CF in patients at a major CF center in Turkey.
- The analysis involved 481 individuals, revealing 136 different CFTR variants and identifying novel variants specific to the Turkish population, indicating unique genetic characteristics compared to averages in the US and Europe.
- The findings emphasize the importance of comprehensive genetic profiling in diverse populations to improve personalized treatment for CF, especially in light of new CFTR modulators.
Article Synopsis
- - Cystic fibrosis (CF) is caused by mutations in the CFTR gene, with over 2000 identified variants, and new drugs called CFTR modulators are only effective for patients with specific variants, leading to disparities in access based on race and location.
- - A study at Marmara University reviewed 445 CF patients, finding that 31.2% were ineligible for CFTR modulators, identifying 60 different variants, most of which were missense or nonsense types, with c.1545_1546del being the most common in that region.
- - The research emphasizes the need for detailed genetic testing of CF patients who can't use current drugs, suggesting that new strategies must be developed to ensure all patients
The presence of polybrominated diphenyl ethers (PBDEs) in the car is due to their use as a flame retardant additive in various car components such as dashboard, plastic parts, seat and headliner cushion foams, insulated cables, and electronic circuits. Ingestion of dust inadvertently or dermal contact to dust are significant pathways of human exposure to pollutants including PBDEs. There are no studies documenting presence of car dust associated flame retardants in Turkey.
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