Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines.

In the present investigation, the anti-inflammatory activity of isolated bergapten from hydroalcoholic extract of Heracleum nepalense root was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs). Bergapten exhibited significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α (TNF-α) and interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide in a concentration-dependent manner.

In vivo evaluation of antidiarrhoeal activity of Rhus semialata fruit extract in rats.

Rhus semialata Murr. (Anacardiaceae) is a deciduous tree of north eastern India. The fruit of this plant is traditionally used to control diarrhoea and dysentery.