Publications by authors named "Sekar K"

Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably, it is observed that mesoscale alignment in the flow direction does not develop simultaneously across nano-micro lengthscales in sheared suspensions of rod-like chiral-nematic (meso) phase forming cellulose nanocrystals. Rather, with increasing shear rate, orientation is observed first at mesoscale and then extends to the nanoscale, with influencing factors being the aggregation state of the hierarchy and concentration.

View Article and Find Full Text PDF

Mosquito-borne illnesses pose a significant threat to eradication under existing vector management measures. Chemo-based vector control strategies (use of insecticides) raise a complication of resistance and environmental pollution. Biological control methods are an alternative approach to overcoming this complication arising from insecticides.

View Article and Find Full Text PDF

Background Aims: Oral wound healing involves hemostasis, inflammation, proliferation and tissue remodeling. The oral cavity is a complex wound healing environment because of the presence of saliva, a high bacterial burden and ongoing physical trauma from eating. The inflammatory component of wound healing balances the polarization of macrophages in healing tissues between M1 inflammatory macrophages and M2 anti-inflammatory macrophages.

View Article and Find Full Text PDF

In India, the Trans-Himalayan zone lies in the rain shadow of the main Himalayan region and is usually described as a "high-altitude cold desert". These regions are represented by sparse but unique vegetation composition. The present study is an attempt to investigate the vegetation composition in the alpine ecosystem of the cold desert landscape of the Nelang Valley in Western Himalayas (Uttarakhand), India.

View Article and Find Full Text PDF

Objective: This quality improvement project aimed to reduce central line bacteremias (central line-associated bloodstream infections [CLABSIs]) in a neonatal ICU (NICU) to a CLABSI rate of zero using a clinical nurse specialist (CNS)-led neonatal peripherally inserted central catheter (PICC) team.

Background: The NICU at the study site was experiencing more than twice the National Healthcare Safety Network average CLABSI rate at 2.2 per 1000 line-days with an estimated cost of $2 072 806 to the organization.

View Article and Find Full Text PDF

Background Carotid wall abnormalities are significant predictors of cardiovascular events, including ischemic stroke. Identifying the clinical and biochemical risk factors associated with these abnormalities can aid in early intervention and prevention strategies. This study aimed to assess the association between lipid profiles, age, gender, smoking habits, hypertension, and carotid wall abnormalities in patients.

View Article and Find Full Text PDF

In recent days, in tropical and subtropical regions, secondary vectors of Anopheles mosquitoes are becoming more important in transmitting diseases to humans as primary vectors. Various molecular techniques have separated closely related Anopheles subpictus and Anopheles vagus mosquitoes based on their diversity with other mosquito species. Despite their widespread distribution, the An.

View Article and Find Full Text PDF

Cancer cells need nutrients to grow and proliferate. During nutrient stress in the microenvironment, it is unclear or cancer cells can adopt alternative resources to re-wire and survive in patients. We discovered a 6-factor-secretome remarkably sustains a critical cell mass during nutrient stress in a pediatric embryonal brain tumor, atypical teratoid rhabdoid tumor (ATRT).

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the properties and passivation of methylammonium lead triiodide (MAPbI) used in perovskite solar cells, finding a tetragonal crystal structure with a slight excess of PbI at grain boundaries.
  • Optical tests show MAPbI has a band gap of 1.53 eV, suggesting its effectiveness as a visible light absorber for solar energy applications.
  • Simulations predict a maximum power conversion efficiency (PCE) of 26.03% for optimized solar cell designs, highlighting the importance of various parameters like resistance and device structure in improving efficiency.
View Article and Find Full Text PDF

Unlabelled: Zika virus (ZIKV) and Dengue virus (DENV) infections cause severe disease in humans and are significant socio-economic burden worldwide. These flavivirus infections are difficult to diagnose serologically due to antigenic overlap. The phylogenetic analysis shows that ZIKV clusters with DENVs at a higher node of the phylogenetic tree with significant genomic and structural similarity.

View Article and Find Full Text PDF

The development of efficient and stable electrocatalysts is crucial for the advancement of green and clean hydrogen energy technologies. In this work, we synthesized a nanocomposite of nickel-iron layered double hydroxide/molybdenum titanium carbide (NiFe-LDHs/MoTiC) using a deep eutectic solvent (DESs) by the solvothermal method. The formation of NiFe-LDHs/MoTiC nanocomposite was confirmed by various electron microscopic and spectroscopic techniques.

View Article and Find Full Text PDF

Soil efflux of CO ( ) is known to be dependent on natural drying and rewetting of the soil. Although the central Indian Himalayan region is predominantly occupied with two ecosystems, i. e.

View Article and Find Full Text PDF

Carinal resection of tumour involving trachea and carina remains as a challenge for thoracic surgeons and anaesthesiologists. Resection is technically demanding and can be associated with significant morbidity and mortality. In this case report, we describe the successful management of carinal tumour with carinal resection in a 45-year-old female.

View Article and Find Full Text PDF

Studying the relationship between sequences and their corresponding three-dimensional structure assists structural biologists in solving the protein-folding problem. Despite several experimental and in-silico approaches, still understanding or decoding the three-dimensional structures from the sequence remains a mystery. In such cases, the accuracy of the structure prediction plays an indispensable role.

View Article and Find Full Text PDF
Article Synopsis
  • - The insulin superfamily proteins (ISPs) evolved from a common ancestor, leading to insulin, IGFs, and relaxin, which have different functions but similar structures due to conserved disulphide bridges.
  • - A comprehensive analysis of 427 sequences reveals that IGFs show over 90% sequence conservation, suggesting their interactions with multiple partners limit sequence diversity.
  • - The study also updates the receptor-binding motifs for relaxin, identifies a possible non-canonical C-peptide cleavage site in some insulin sequences, and proposes insulin mutants for therapeutic use based on structural modifications seen in related proteins.
View Article and Find Full Text PDF
Article Synopsis
  • Myxobacteria are unique predatory bacteria known for their antimicrobial properties and complex mechanisms for killing prey, making them a focus of antibiotic research.
  • MyxoPortal is an extensive genomic database featuring 262 genomes of different myxobacterial strains, providing detailed annotations on genes, functions, and evolutionary relationships.
  • The database also includes biosynthetic gene clusters, antimicrobial peptide sequences, and other genomic data, making it a valuable resource for researchers studying myxobacteria's potential in antimicrobial and ecological research.
View Article and Find Full Text PDF

In this work, we demonstrate an interface on porous nickel foam (NN) between crystalline nickel sulfide and amorphous nickel sulfide (NNS/NNS) adapting simple hydrothermal and facile electrodeposition processes, respectively. The developed electrocatalyst required a low overpotential of 15 mV to deliver a current density of 10 mA cm and the interface intrinsically activates the electrocatalyst with an onset overpotential comparable to that of Pt in an alkaline hydrogen evolution reaction.

View Article and Find Full Text PDF
Article Synopsis
  • Hepatocellular carcinoma (HCC) is a dangerous type of cancer that is different inside each tumor, making it hard to treat.
  • Researchers studied over 600 samples from 123 patients to understand how this cancer develops and progresses.
  • They discovered that the most aggressive cells in a tumor are the best way to predict how well a patient will do, not just by looking at how different the tumor cells are from each other.
View Article and Find Full Text PDF

In perovskite solar cells (PSCs), the charge carrier recombination obstacles mainly occur at the ETL/perovskite and HTL/perovskite interfaces, which play a decisive role in the solar cell performance. Therefore, this study aims to enhance the flexible PSC (FPSC) efficiency by adding the newly designed CBz-PAI-interlayer (simply CBz-PAI-IL) at the perovskite/HTL interface. In addition, substantial work has been carried out on five different HTLs (Se/Te-CuO, CuGaO, VO and CuSCN, including conventional Spiro-OMeTAD as a reference HTL with and without CBz-PAI-IL), using drift-diffusion simulation to find suitable FPSC design to attain the maximum PCE.

View Article and Find Full Text PDF

Protein dynamics linked to numerous biomolecular functions, such as ligand binding, allosteric regulation, and catalysis, must be better understood at the atomic level. Reactive atoms of key residues drive a repertoire of biomolecular functions by flipping between alternate conformations or conformational substates, seldom found in protein structures. Probing such sparsely sampled alternate conformations would provide mechanistic insight into many biological functions.

View Article and Find Full Text PDF

Freshwater depletion is an alarm for finding an eco-friendly solution to treat wastewater for drinking and domestic applications. Though several methods like chlorination, filtration, and coagulation-sedimentation are conventionally employed for water treatment, these methods need to be improved as they are not environmentally friendly, rely on chemicals, and are ineffective for all kinds of pollutants. These problems can be addressed by employing an alternative solution that is effective for efficient water treatment and favors commercial aspects.

View Article and Find Full Text PDF

Due to their excellent properties, Zinc oxide nanowires (ZnO NW) have been attractive and considered as a promising electron-transporting layer (ETL) in flexible Perovskite Solar Cells (FPSCs). Since the first report on ZnO NWs-based FPSCs giving 2.6 % power conversion efficiency (in 2013), great improvements have been made, allowing to reach up to∼15 % nowadays.

View Article and Find Full Text PDF

Background: Stress and distress are common among Mental Health Professionals (MHP). MHPs avoid seeking professional help to address their stress, leading to increased vulnerability to stress and mental health conditions. Inadequately addressed stress directly impacts their service delivery and well-being.

View Article and Find Full Text PDF

Background: Police personnel experience the highest levels of stress due to the nature and demands of work. Though many researchers have studied these variables quantitatively, there is a lack of qualitative study, particularly in India.

Methods: A qualitative study has been carried out to explore the stress and coping strategies of police personnel.

View Article and Find Full Text PDF

Background: Crohn's disease (CD) is a chronic idiopathic inflammatory bowel disease affecting the entire gastrointestinal tract from the mouth to the anus. These patients often experience a period of symptomatic relapse and remission. A 20 - 30% symptomatic recurrence rate is reported in the first year after surgery, with a 10% increase each subsequent year.

View Article and Find Full Text PDF