Peel Essential Oil-Induced Type IV Hypersensitivity Reaction.

Background: Several studies have shown anti-inflammatory, anti-microbial, antifungal, and antioxidant effects from -peel essential oil (Cl-PEO). Cl-PEO can be developed as topical drugs for oral ulceration because of its potential active components. There have been no studies on the topical application of Cl-PEO inducing type IV hypersensitivity reaction.