Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year.

Background: To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy.

Design: Prospective, non-randomized, comparative study.

Participants: Sixty-six Asian patients.

Initial management of acute primary angle closure: a randomized trial comparing phacoemulsification with laser peripheral iridotomy.

Purpose: To compare the 2-year efficacy of phacoemulsification and intraocular lens implant (phaco/IOL) with laser peripheral iridotomy (LPI) in the early management of acute primary angle closure (APAC) and coexisting cataract.

Design: Randomized, controlled trial.

Participants: We included 37 subjects presenting with APAC who had responded to medical treatment such that intraocular pressure (IOP) was ≤30 mmHg within 24 hours, and had cataract with visual acuity of ≤6/15.

Anterior segment imaging in the management of postoperative fibrin pupillary-block glaucoma.

Postoperative fibrin pupillary-block glaucoma, an uncommon complication of intraocular surgery, develops when an inflammatory fibrin membrane occludes the pupil, resulting in peripheral angle closure. We present a series of 4 patients with this condition and describe the role of anterior segment optical coherence tomography and ultrasound biomicroscopy in distinguishing fibrin pupillary-block glaucoma from other forms of postoperative acute glaucoma. Specific to this condition is the presence of a fibrin membrane across the pupil and accumulation of aqueous in the posterior chamber, as would be expected in pupil block, but with a clear separation between the intraocular lens and the iris.

Glaucoma management in patients with osteo-odonto-keratoprosthesis (OOKP): the Singapore OOKP Study.

Purpose: To report diagnostic modalities and treatment options for glaucoma in eyes with osteo-odonto keratoprosthesis (OOKP).

Methods: Eyes that underwent OOKP were evaluated for glaucoma at the time of the first postoperative visit, then at 1 and 3 months after the procedure, and thereafter every 6 months. All eyes underwent stereo-biomicroscopic optic nerve head (ONH) assessment, kinetic (Goldmann perimetry) and automated static visual field testing, ONH photography, Heidelberg retina tomograph, scanning laser polarimetery (GDx), and optical coherence tomography.

Efficacy and safety of a systematic switch from latanoprost to travoprost in patients with glaucoma.

Purpose: To assess the efficacy and safety of systematically switching a large number of hospital-based glaucoma patients from latanoprost to travoprost therapy.

Materials And Methods: In this prospective observational study, patients on latanoprost were systematically switched to travoprost without washout and followed-up for 12 weeks. The main outcome measures were control of intraocular pressure (IOP), rate of switching back, and tolerability.

Evaluating the optic nerve and retinal nerve fibre layer: the roles of Heidelberg retina tomography, scanning laser polarimetry and optical coherence tomography.

Introduction: For many years, ophthalmologists have looked at the optic nerve head to evaluate the status of glaucoma. Clinical examination of the optic nerve head and retinal nerve fibre layer (RNFL) is however, subjective and sometimes variable. Recent developments in computer-based imaging technologies have provided a means of obtaining quantitative measurements of the optic nerve head topography and peripapillary retinal nerve fibre layer thickness.

Comparison of the scanning peripheral anterior chamber depth analyzer and the modified van Herick grading system in the assessment of angle closure.

Purpose: To compare the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and the modified van Herick grading system in the assessment of angle closure, using gonioscopy as the reference standard.

Design: Prospective comparative study.

Participants: One hundred twenty phakic subjects (53 with primary angle closure and 67 with open angles) with no history of laser or intraocular surgery.

Myopia, axial length, and OCT characteristics of the macula in Singaporean children.

Purpose: The purpose of this study was to evaluate the associations between macular volume and thickness, as assessed by optic coherence tomography (OCT), with refraction and axial length (AL) in children.

Methods: A total of 104 Chinese school children (51 girls and 53 boys) 11 to 12 years of age were randomly selected from one school during the 2005 examination in the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Cycloplegic autorefraction was performed to obtain refraction (defined as spherical equivalent [SE]) and ultrasound biometry performed to obtain the AL.

Peripapillary retinal nerve fiber layer thickness variations with myopia.

Purpose: To determine the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness and myopia using optical coherence tomography (OCT).

Design: Prospective observational case series.

Methods: One hundred thirty-two young males with myopia (spherical equivalent [SE], -0.

Use of surodex in phacotrabeculectomy surgery.

Purpose: To evaluate the use of Surodex (Oculex Pharmaceuticals, Sunnyvale, California) a drug delivery system incorporating 60 micrograms of dexamethasone in a pellet, in phacotrabeculectomy surgery.

Design: Nonrandomized, prospective, interventional case series.

Methods: Phacotrabeculectomy was performed on 37 Asian subjects with primary open-angle glaucoma (POAG) using a standardized technique.

Use of optical coherence tomography to assess variations in macular retinal thickness in myopia.

Purpose: To investigate the variation in macular retinal thickness in otherwise normal young Asian myopic subjects by using optical coherence tomography (OCT).

Methods: One hundred thirty ophthalmically normal men 19 to 24 years of age with myopia (spherical equivalent, -0.25 to -14.

Medical management of angle closure glaucoma.

Management of angle closure glaucoma requires an understanding of the underlying pathophysiologic mechanisms. Treatment is aimed at eliminating pupillary block and other causes of angle closure, re-opening the angle, and preventing further damage to the optic nerve by lowering intraocular pressure. Medical therapy plays an important role in the successful management of this condition.

Changes in retinal nerve fiber layer thickness after acute primary angle closure.

Purpose: To evaluate the changes in retinal nerve fiber layer (RNFL) thickness in the first 16 weeks after acute primary angle closure (APAC) using scanning laser polarimetry (SLP).

Design: Prospective, observational case series.

Participants: Thirty-seven Asian subjects with APAC.

Assessment of optic disc anatomy and nerve fiber layer thickness in ocular hypertensive subjects with normal short-wavelength automated perimetry.

Purpose: To compare optic disc topography and nerve fiber layer thickness in ocular hypertensive eyes and normal subjects.

Design: Prospective, case-controlled study.

Participants And Controls: One eye in each of 20 normal and 27 ocular hypertensive patients was enrolled.