Publications by authors named "Sejal Suri"

The paucity of targeted therapies for triple-negative breast cancer (TNBC) causes patients with this aggressive disease to suffer a poor clinical prognosis. A promising target for therapeutic intervention is the Wnt signaling pathway, which is activated in TNBC cells when extracellular Wnt ligands bind overexpressed Frizzled7 (FZD7) transmembrane receptors. This stabilizes intracellular β-catenin proteins that in turn promote transcription of oncogenes that drive tumor growth and metastasis.

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Synopsis of recent research by authors named "Sejal Suri"

  • - Sejal Suri's recent research focuses on developing innovative therapeutic strategies targeting the Wnt signaling pathway to treat triple-negative breast cancer (TNBC), a subtype known for its poor prognosis due to limited targeted therapies
  • - The study highlights the use of antibody and siRNA nanocarriers as a means to suppress Wnt signaling, ultimately aiming to inhibit tumor growth and lung metastasis in TNBC models
  • - Findings suggest that disrupting the interaction between extracellular Wnt ligands and Frizzled7 (FZD7) receptors could potentially lead to significant advancements in treatment options for patients suffering from this aggressive cancer type

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