Publications by authors named "Seiyu Jeong-Yoo Ohtani-Kim"
Purpose: We elucidated the effects of planned resection volume on postoperative pulmonary function and changes in residual lung volume during segmentectomy.
Methods: This study included patients who underwent thoracoscopic segmentectomy between January 2017 and December 2022 and met eligibility criteria. Pre- and post-resection spirometry and computed tomography were performed.
Article Synopsis
- The study assessed the spatial variability of PD-L1 protein expression in non-small cell lung cancer (NSCLC) and how it affects patient outcomes after surgery.
- Researchers analyzed data from 239 NSCLC specimens, using a mathematical model that examined the texture of images to determine the heterogeneity index for PD-L1, linking it to tumor characteristics and survival rates.
- Findings revealed that a high heterogeneity index of PD-L1 is associated with poorer recurrence-free survival, particularly in specific histological subtypes, establishing it as an independent risk factor for tumor recurrence.
The 2021 World Health Organization (WHO) classification system for thoracic tumors (including lung cancer) contains several updates to the 2015 edition. Revisions for lung cancer include a new grading system for invasive nonmucinous adenocarcinoma that better reflects prognosis, reorganization of squamous cell carcinomas and neuroendocrine neoplasms, and description of some new entities. Moreover, remarkable advancements in our knowledge of genetic mutations and targeted therapies have led to a much greater emphasis on genetic testing than that in 2015.
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- A new histologic grading system for invasive lung adenocarcinomas (LUAD) has been adopted by the World Health Organization (WHO), and this study evaluates its effectiveness in predicting tumor grades from preoperative biopsies compared to surgically resected samples.
- The study analyzed 222 patient samples, finding an overall concordance rate of 81.5% between biopsy and surgical grades, with higher accuracy for well-differentiated (grade 1) and poorly differentiated (grade 3) tumors than for moderately differentiated (grade 2) tumors.
- Factors such as the tumor's invasive diameter impacted concordance rates, indicating that smaller tumors correlated with more accurate grading for grades 1 and 2, while