Phenotypes and Chronic Organ Damage May Be Different among Siblings with Wilson's Disease.

Cloning of ATP7B provided evidence that Wilson's disease is a hepatic copper toxicosis with a variety of extrahepatic complications. Affected siblings with the same genetic background and exposure to similar environmental factors may be a good model for the study of genotype-phenotype correlation. Twenty-three affected siblings in 11 families were selected from a database.