Publications by authors named "Seita Yasuda"
Patients with bipolar disorder often report self-perceived treatment resistance. However, it is not known to what extent it is due to actual treatment resistance. The Juntendo University provides "Bipolar Disorder Treatment Rebuilding Program," in which patients with self-reported treatment resistant bipolar disorder are hospitalized for 2 weeks and undergo detailed examinations.
View Article and Find Full Text PDFAim: To investigate the real-world effectiveness and safety of lemborexan for treating comorbid insomnia associated with other psychiatric disorders, and whether lemborexant helps reduce the dose of benzodiazepines (BZs).
Methods: This retrospective observational study was conducted on outpatients and inpatients treated by physicians of Juntendo University Hospital Mental Clinic between April 2020 and December 2021.
Results: Data of 649 patients who were treated with lemborexant were eventually enrolled.
Article Synopsis
- The study investigates the relationship between the ε4 allele of the apolipoprotein E gene (APOE4) and the recurrence of depression in patients diagnosed with major depressive disorder (MDD) after achieving remission.
- It followed 163 patients, comparing APOE4 carriers and non-carriers, finding that carriers had a significantly higher likelihood of experiencing subsequent depression recurrences.
- Limitations include variations in antidepressant treatments among participants, a mix of first-time and recurrent depression episodes, and insufficient data to analyze different genetic variants of APOE4 on recurrence risk.
Serum levels and mutual correlations of amyloid β in patients with depression.
Geriatr Gerontol Int
February 2020
Aim: Epidemiological studies have shown that depression is a risk factor for Alzheimer's disease (AD). Although the biological mechanism underlying the link between depression and AD is unclear, altered amyloid β (Aβ) metabolism in patients with depression has been suggested as a potential mechanism. Results from previous studies of Aβ metabolism in patients with depression have been inconsistent, and Aβ polymerization, which is a crucial process in AD pathology, has not previously been assessed.
View Article and Find Full Text PDFBackground: Recent reports have suggested a relationship between affective disorder including depression and bipolar disorder (BP) and frontotemporal dementia (FTD). TAR DNA binding protein (TDP) -43 is a protein found in the brain and peripheral fluid of patients with FTD. To examine a possible association between affective disorders and FTD, serum levels of TDP-43 were evaluated in late-life patients with major depressive episode (MDE).
View Article and Find Full Text PDFIncreased Serum Levels of α-Synuclein in Patients With Major Depressive Disorder.
Am J Geriatr Psychiatry
March 2019
Article Synopsis
- Depression is a significant risk factor for developing dementia, particularly dementia with Lewy bodies (DLB), and is linked to elevated levels of α-synuclein in the body.
- A study compared serum α-syn levels between 103 patients with major depressive disorder (MDD) and 132 healthy individuals, revealing that MDD patients had significantly higher α-syn levels regardless of age.
- These findings indicate that depression may not just be an early warning sign of DLB but also a potential contributor to its development.