Publications by authors named "Seimi Watanabe"
Although cardiac troponin is a highly specific biomarker for myocardial cell injury, it is important to recognize the pitfalls of this test in the diagnosis and management of immune checkpoint inhibitor (ICI) myocarditis. We describe the challenging case of an 81-year-old woman with persistently high troponin after undergoing immunotherapy with ipilimumab and nivolumab, and histological evidence of amyloid deposition in the myocardium. The patient received immunosuppressive treatments based on the magnitude of troponin changes because myocarditis was clinically suspected.
View Article and Find Full Text PDFWe report a case of eosinophilic fasciitis triggered by strenuous physical activity, which did not relapse during the follow-up period. We ascertained that interleukin-33 (IL-33) was released from the vascular endothelial cells after intense exercise, inducing type 2 innate lymphocytes (ILC2) and causing fasciitis. A healthy woman experienced itching on both limbs a few hours after a game of drumming.
View Article and Find Full Text PDFArticle Synopsis
- Pyoderma gangrenosum (PG) is a rare inflammatory skin condition that causes painful ulcers, primarily on the legs and trunk.
- First-line treatments typically involve systemic corticosteroids for wound healing, but some cases respond well to tumor necrosis factor-α inhibitors like adalimumab and infliximab.
- In a reported case, oral prednisolone and skin grafting were used for severe PG, and while mechanical debridement struggled to promote healing, a vacuum-assisted closure (VAC) system proved effective after PG activity stabilized.