Publications by authors named "Seiko N Doi"
J Card Fail
November 2024
Article Synopsis
- The Heart Failure Collaboratory (HFC) score evaluates pharmacotherapy for heart failure patients, and this study analyzed its impact in 1116 Danish patients with nonischemic heart failure with reduced ejection fraction (HFrEF).
- A lower modified HFC (mHFC) score was linked to increased all-cause mortality, while an mHFC score of 3-4 had better outcomes compared to scores of 1-2.
- Despite these findings, implanting cardioverter-defibrillators (ICDs) did not improve overall or cardiovascular survival rates in these patients, although it did reduce sudden cardiovascular deaths.
Eur J Heart Fail
June 2024
Article Synopsis
- Current guidelines recommend implantable cardioverter-defibrillator (ICD) therapy for patients with heart failure and left ventricular ejection fraction ≤35%, but the benefits of ICDs in patients with NYHA class III remain uncertain.
- The DANISH trial studied 1116 patients and found that those in NYHA class III/IV had higher long-term all-cause and cardiovascular mortality rates compared to those in NYHA class II.
- Despite these findings, ICD implantation did not significantly reduce all-cause or cardiovascular mortality rates in either NYHA class, indicating a limited benefit of ICD therapy for this patient population.
Article Synopsis
- * The study analyzed data from Danish nationwide registries, including over 14,000 sarcoidosis patients, and revealed an increased hazard ratio for VTE shortly after diagnosis and even after a year.
- * Overall mortality rates for patients experiencing VTE did not significantly differ between those with sarcoidosis and those without, suggesting that the presence of sarcoidosis increases VTE risk but not necessarily mortality from it.
J Am Heart Assoc
February 2024
Article Synopsis
- A study examined the long-term impacts of implantable cardioverter-defibrillators (ICDs) on patients with heart failure and chronic kidney disease (CKD), comparing ICD outcomes to usual care.*
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- The study included 1116 patients, with findings showing that ICD implantation did not significantly lower overall mortality or cardiovascular death rates, regardless of CKD status.*
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- However, ICDs were effective in reducing sudden cardiovascular deaths in both patients with and without CKD over a median follow-up of 9.5 years.*
