Publications by authors named "Seiko Fujii"

Purpose: A method was developed to measure strabismic angles >50 by stacking commercially available Fresnel and block prisms in the same direction ("piggyback prisms").

Methods: With a laser pointer (wavelength of 532 nm) as the light source, the deviation of the laser spot produced by the stacked prisms was measured on a tangent screen placed 100 cm away from the prisms. To the obtained data with combinations of Fresnel prisms (5-40) and block prisms (10-50), a cubic surface function was fitted by polynomial regression.

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Japan has 16 native species of the genus Tratt. (Asparagaceae). A recent study on based on field surveys and molecular phylogenetic analyses resulted in the discovery of six unknown taxa in Kochi Prefecture, Shikoku Island, southwestern Japan.

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The early diagnosis and isolation of infected individuals with coronavirus disease 2019 (COVID-19) remain important. Although quantitative polymerase chain reaction (qPCR) testing is considered the most accurate test available for COVID-19 diagnosis, it has some limitations, such as the need for specialized laboratory technicians and a long turnaround time. Therefore, we have established and reported a rapid diagnostic method using a small amount of saliva as a sample using a lightweight mobile qPCR device.

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Reconstruction of the mandible following hemimandibulectomy is difficult and complex. The appropriate approach to condylar reconstruction remains controversial. In this report, the authors propose the concept of "short ramus reconstruction" after hemimandibulectomy.

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Article Synopsis
  • Histone deacetylase (HDAC) is crucial for gene regulation and has become a target for anti-inflammatory therapies through its impact on cellular growth and differentiation.
  • The study focused on Ky-2, a hybrid HDAC inhibitor, which demonstrated its ability to inhibit HDAC2 and promote histone H3 acetylation in THP-1 monocytes, converting them into M1 macrophages.
  • Treatment with Ky-2 reduced the inflammatory cytokine IL-1β and its related pathways in LPS-stimulated THP-1 cells, indicating potential anti-inflammatory effects and suggesting that it could help regulate M1 macrophage polarization.
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Small-molecule synthesis usually relies on procedures that are highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process.

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Objectives: Histone deacetylase (HDAC) inhibitors are new therapeutic agents, used to treat various types of malignant cancers. In the present study, we investigated the effects of Ky-2, a hybrid-compound HDAC inhibitor, on the growth of mouse myeloma cells.

Materials And Methods: Myeloma cells, HS-72, P3U1, and mouse normal cells were used in this study.

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