Therapeutic Strategy for Rheumatoid Arthritis by Induction of Myeloid-Derived Suppressor Cells with High Suppressive Potential.

Combination treatment using fingolimod (FTY720), an immunomodulator, and a pathogenic antigen prevents the progression of glucose-6-phosphate isomerase (GPI)-induced arthritis. In this study, we focused on myeloid-derived suppressor cells (MDSCs; CD11bGr-1 cells) and investigated the effects of the combination treatment on these cells. DBA/1J mice with GPI-induced arthritis were treated using FTY720 and/or GPI for five days.