Publications by authors named "Seijiro Hamada"
Background: Olfactory neuroblastoma (ONB) is a rare malignant tumor arising from the olfactory neuroepithelium. The standard of care for ONB is surgical resection; however, detailed treatment protocols vary by institution. Our treatment protocol consists of endoscopic skull base surgery (ESBS) for endoscopically resectable cases and induction chemotherapy followed by craniotomy combined with ESBS for locally advanced cases, with postoperative radiotherapy performed for all cases.
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- Photoimmunotherapy uses a targeted drug activated by infrared light to induce cell death in tumors, but accurately placing the necessary illumination devices for deep lesions is challenging during surgery.* -
- The development of "SlicerPIT," a planning software, allows for effective preoperative placement of illumination devices in 2D and 3D, improving guidance during actual procedures through integration with surgical navigation systems.* -
- In trials with three patients, SlicerPIT successfully guided the placement of treatment devices, yielding positive results with tumor necrosis and shrinkage, indicating its potential to enhance photoimmunotherapy outcomes.*
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- Tri-weekly cisplatin (CDDP) combined with radiotherapy (RT) is the standard treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), but it's tough for older patients, prompting a study on weekly CDDP + RT instead.
- The study focused on patients aged 70 and older, analyzing treatment outcomes for those who received weekly CDDP + RT from 2006 to 2022, measuring overall survival (OS), progression-free survival (PFS), and cause-specific survival (CSS).
- Results indicated that patients had a median age of 72, with high survival rates over 3 years: 80.9% OS, 68.3% PFS
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- Mucosal melanoma, particularly sinonasal mucosal melanoma (SNMM), is a rare yet aggressive cancer with higher incidence in Asians, lacking established targeted therapies compared to cutaneous melanoma which often involves BRAF mutations.* -
- In a study analyzing 18 tissue samples, 44% showed genetic mutations, with NRAS being the most common; however, clinical outcomes differed minimally between patients with and without mutations.* -
- No BRAF V600 mutations were found, and while NRAS mutations indicated a potential for worse survival rates, the differences were not statistically significant, highlighting the need for further research into the genetic landscape of SNMM.*
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- The study evaluates a treatment strategy for sinonasal mucosal melanoma using endoscopic resection and postoperative radiotherapy in 30 patients over nearly two decades.
- Results indicated that 75% of patients had successful resection via endoscopy, but 70% experienced recurrence, with a high rate of distant metastasis observed.
- The overall survival rates were 70% at 2 years and 46% at 5 years, highlighting the need for improved control of distant metastasis to enhance treatment outcomes.
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- Superselective intra-arterial infusion of cisplatin combined with radiotherapy (RADPLAT) is being studied as a treatment for advanced head and neck squamous cell carcinoma, raising concerns about its effectiveness against neck lymph node metastasis.
- The study analyzed 172 patients with neck lymph node metastases, comparing the outcomes of 66 patients receiving RADPLAT to 106 receiving intravenous chemoradiotherapy (IV-CRT), using advanced statistical methods to balance patient backgrounds.
- Results showed that, after adjustments, the RADPLAT group had a slightly better regional control rate (86.6%) compared to the IV-CRT group (79.4%), indicating RADPLAT is a viable treatment option even for patients
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- SLFN11 has been identified as a potential biomarker that enhances cancer cell sensitivity to DNA damage caused by platinum-based treatments, which could help predict patient outcomes in chemoradiotherapy (CRT) for head and neck squamous cell carcinoma (HNSCC).
- A study involving 161 HNSCC patients showed that those with higher SLFN11 expression experienced significantly better progression-free survival (PFS) rates compared to those without it (78.8% vs. 52.8%).
- Investigations also revealed that lower SLFN11 expression in tumors was linked to local treatment failures and that knocking out SLFN11 in cancer cell lines decreased sensitivity to DNA-damaging therapies, indicating its potential role in treatment response.
Objective: Esophageal cancer is the most common second primary cancer (SPC) in patients with head and neck cancer (HNC). Esophageal SPC has a negative impact on survival. Elevated mean corpuscular volume (MCV) is an accepted predictor of esophageal cancer risk.
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- In head and neck cancers, assessing histopathological information helps determine tumor characteristics and prognosis, with this study focusing on the effectiveness of diffusion-weighted T2 (DW-T2) mapping in analyzing histological grades in head and neck squamous cell carcinoma (SCC).
- An analysis of 41 patients revealed that ADC values were significantly lower in poorly differentiated SCC compared to well/moderately differentiated SCC, highlighting differences in imaging metrics between these groups.
- DW-T2 mapping shows promise as a supportive tool for determining tumor grades, indicating potential for improved diagnosis and treatment planning in patients with head and neck SCC.
The aim of this study was to investigate the utility of amide proton transfer (APT) imaging for the determination of human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (SCC). Thirty-one patients with oropharyngeal SCC were retrospectively evaluated. All patients underwent amide proton transfer imaging using a 3T magnetic resonance (MR) unit.
View Article and Find Full Text PDFBackground: We investigated whether prophylactic percutaneous endoscopic gastrostomy (PEG) is used effectively for patients treated with definitive concurrent chemoradiotherapy (CCRT) and the predictors of the need for PEG.
Methods: 326 patients with laryngeal, oropharyngeal or hypopharyngeal cancers were retrospectively reviewed.
Results: The PEG tube use group had more favorable results than the total parenteral nutrition and nasogastric tube groups in terms of rate of serum albumin loss, incidence of severe fever and aspiration pneumonia, CCRT completion rate and hospitalization period.
Parotid gland tumor with facial nerve paralysis is strongly suggestive of a malignant tumor. However, several case reports have documented benign tumors of the parotid gland with facial nerve paralysis. Here, we report a case of oncocytoma of the parotid gland with facial nerve paralysis.
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