Safety and efficacy of aggressive exercise therapy for patients with unilateral early-stage spondylolysis: A retrospective comparative cohort study.

Introduction: Bony union in patients with early-stage spondylolysis can be achieved using a rigid corset and avoiding sports activities. However, prolonged absence from sports activities may decrease physical fitness. This study aimed to investigate the safety and efficacy of aggressive exercise therapy for patients with early-stage spondylolysis (ESS).

The Analgesic and Side Effects of Tramadol Hydrochloride Immediate-Release and Extended-Release Tablets in Patients With Chronic Low Back Pain.

Overview Of Literature:  There are no established treatments for low back pain. Conventional treatments include physiotherapy and pharmacological treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs). Recently, analgesics with mechanisms of action different from those of NSAIDs have emerged.

Effect of the suture augmentation on the stability and strength of ulnar collateral ligament reconstruction: The anchor and bone tunnel methods.

Background: The initial fixation strength of the ulnar collateral ligament (UCL) reconstruction is increased by combining a suture augmentation (SA). However, no reports have investigated the stability of UCL reconstruction with SA across multiple elbow flexion angles and the influence of SA on the stability and failure strength of the anchor and bone tunnel methods. This study aimed to compare the displacement against a valgus load at multiple elbow flexion angles of the anchor and bone tunnel methods between with and without SA, and to compare the failure strength between these methods with SA.

Radiographic Predictors of Lateral Translation in Patients With Residual Adolescent Idiopathic Scoliosis and Thoracolumbar/Lumbar Curves: A Focus on L3 Lateral Translation.

Background: Patients with residual adolescent idiopathic scoliosis (AIS) and thoracolumbar/lumbar curves may present with progression after cessation of growth, with lateral translation as a major risk factor. Nonetheless, radiographic predictors and underlying mechanisms remain indefinite. This study aimed to determine these radiographic predictors and structural mechanisms in patients with residual AIS.

A Suture Method for Collateral Ligaments of the Finger Proximal Interphalangeal Joint: A Cadaver Study.

Purpose: In a cadaveric model, a comparison was made of the strength of a suture method for collateral ligaments (the N method) with that of simple sutures using suture anchors for the repair of collateral ligaments in the proximal interphalangeal joint.

Methods: We obtained 72 fingers from 18 upper limbs of fresh-frozen cadavers and compared the left and right sides of the same specimens. In experiment 1, we examined the rupture strength and rupture sites of intact collateral ligaments in 24 fingers.

Comparison of effects of intra-articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model.

Diclofenac etalhyaluronate (DF-HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long-term analgesia in osteoarthritis. In this study, the effects of DF-HA on pain improvement and osteoarthritis were evaluated in a rat knee monoiodoacetate-induced osteoarthritis model compared to HA. Eight rats per group had been injected with monoiodoacetate (2.

Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic polyarthritis. It is well-established that helper T cells play crucial roles in the development and deterioration of RA. Recent studies also revealed the significant roles of regulatory T (Treg) cells in this context.

Risk factors for postoperative ileus after corrective spinal surgery: association with reduction in the retrocrural space area.

Objective: The objective of this study was to determine whether a reduction in the retrocrural space (RCS) area is a risk factor for postoperative ileus (POI) in patients with adult spinal deformity (ASD) treated with spinal corrective surgery.

Methods: In total, 100 patients (mean age 67.5 ± 8.

Longitudinal Evaluation Using the Forgotten Joint Score-12 for Double-Bundle Primary Anterior Cruciate Ligament Reconstruction: A Retrospective Observational Study.

Introduction There are several postoperative evaluation methods for anterior cruciate ligament reconstruction (ACLR), and patient-reported outcome measurement (PROM) is one of the most important for evaluating postoperative clinical results. However, conventional PROMs have a high risk of a ceiling effect at one and two years postoperatively and do not accurately reflect functional improvement over time. Therefore, a longitudinal evaluation using PROM with a low risk of ceiling effect is necessary.

Medial Meniscal Extrusion After Anterior Cruciate Ligament Reconstruction (ACLR) Associated With Meniscal Repair and Preoperative Extrusion.

Introduction: The risk of post-traumatic osteoarthritis remains high even after anterior cruciate ligament reconstruction (ACLR). Medial meniscal extrusion (MME) is a valuable clinical sign as an early morphological change. This study aimed to analyze MME before and after ACLR and investigate the factors affecting postoperative MME.

Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale.

Introduction: Platelet-rich plasma obtained by centrifuging peripheral blood can promote osteogenesis owing to its abundant growth factors but has drawbacks, including rapid growth factor loss and inconsistent effects depending on donor factors. To overcome these issues, we were the first in the world to use freeze-dried human induced pluripotent stem cell-derived megakaryocytes and platelets (S-FD-iMPs) and found that they have osteogenesis-promoting effects. Since turbulence was found to activate platelet biogenesis and iPS cell-derived platelets can now be produced on a clinical scale by a device called VerMES, this study examined the osteogenesis-promoting effect and safety of clinical-scale FD-iMP (V-FD-iMPs) for future human clinical application.

Analysis of orthopedic surgery-related incidents in operating rooms using a nationwide incident reporting database.

Background: Patient safety is crucial in high-risk specialties such as orthopedic surgery due to the significant incidence of preventable adverse events. Analyzing extensive databases of orthopedic surgery-related incidents in operating rooms is vital for enhancing medical safety and identifying targeted interventions. This study analyzed orthopedic surgery-related incidents in operating rooms using a nationwide incident reporting database in Japan to identify risk factors associated with severe harm.

Analgesic effects of co-administration of mirogabalin and diclofenac sodium on neuropathic pain in rats.

Co-administration of mirogabalin besylate and nonsteroidal anti-inflammatory drugs is effective for neuropathic pain; however, mechanism of its action remains unknown. We aimed to evaluate the mechanism of this synergistic effect of the concomitant administration for neuropathic pain using chronic constriction injury model rats. Fifty male Wister rats of 7-week-old were used.

Vertebral fracture at the caudal end of diffuse idiopathic skeletal hyperostosis treated with vertebroplasty via double-endplate penetrating screw trajectory and posterior spinal fixation with a new hybrid strategy using cement-augmented fenestrated pedicle screws.

Vertebral fractures in diffuse idiopathic skeletal hyperostosis (DISH) are often unstable. We encountered a case of vertebral fracture at the caudal end of DISH in which vertebroplasty was performed via a double endplate penetrating screw (DEPS) trajectory, and short posterior fixation was performed using the DEPS technique on the cranial vertebrae, including the fractured vertebra; conventional pedicle screw to the caudal vertebrae; and cement-augmented fenestrated pedicle screws to the caudal end vertebra. A 93-year-old man presented with a vertebral fracture at the caudal end of a DISH after a fall.

Automatic generation of diffusion tensor imaging for the lumbar nerve using convolutional neural networks.

【PURPOSE】: Diffusion Tensor Imaging (DTI) with tractography is useful for the functional diagnosis of degenerative lumbar disorders. However, it is not widely used in clinical settings due to time and health care provider costs, as it is performed manually on hospital workstations. The purpose of this study is to construct a system that extracts the lumbar nerve and generates tractography automatically using deep learning semantic segmentation.

Factors influencing the achievement of early surgery in proximal femoral fractures under a Japanese incentive policy.

Background: Proximal femoral fractures in geriatric patients are a major challenge in orthopedics, often leading to major functional impairment. Early surgical intervention is crucial for improving patient recovery and overall health outcomes. Thus, Japan's Ministry of Health, Labour and Welfare initiated a reimbursement policy in April 2022 to encourage early surgery for these fractures in patients aged ≥75 years.