Publications by authors named "Seiji Mabuchi"
Article Synopsis
- Comprehensive genome profiling (CGP) has changed healthcare by paving the way for personalized medicine, but its real-world effectiveness is still uncertain.
- A study at the Osaka International Cancer Institute analyzed data from 1,096 advanced solid tumor patients to assess how often CGP led to suitable therapies and its impact on patient outcomes.
- The findings revealed that while CGP provided clinical trial options for 60.9% of patients, only a small fraction (1.1%) could enroll, and the progression-free survival for treatments was generally short, indicating a need for better integration of CGP into trial systems and patient care.
Article Synopsis
- - The study investigated trends in endometrial cancer incidence and treatment in younger women (under 50) in Japan, focusing on comparing hormonal therapy (HT) to surgery.
- - Data was collected from the Osaka Cancer Registry between 2004 and 2018, revealing a rise in endometrial cancer diagnoses during the potentially reproductive age from 18.5% to 21.9%.
- - Results showed no significant difference in overall survival between patients receiving HT and those undergoing surgery, with both treatment options demonstrating high 5-year survival rates (100% for HT versus 98.8% for surgery).
Seromucinous borderline tumors (SMBT) are papillary neoplasms without invasive capabilities. Originally categorized as ovarian tumors, SMBT, being an endometriosis-related tumor, can manifest beyond the ovaries. To date, only four cases of extraovarian SMBT have been documented in literature.
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- - This study analyzed mortality trends in cervical cancer subtypes (SCC, A, AS, SCNEC) using data from 12,003 patients in Osaka between 1994 and 2018.
- - Results showed that overall survival rates improved for various stages and subtypes of cervical cancer, especially SCC, but not for distant A/AS and SCNEC where survival remained stagnant.
- - The conclusion highlighted that while SCC had better outcomes over the years, SCNEC and advanced A/AS still present significant challenges in treatment, indicating ongoing medical needs in these areas.
Article Synopsis
- The study investigates survival outcomes of stage IVB small-cell neuroendocrine carcinoma (SCNEC) in the cervix compared to other main types of cervical cancer.
- Using data from the Osaka Cancer Registry (1994-2018), researchers analyzed 1158 patients and found SCNEC had the shortest survival rates.
- The results indicate that while current treatments show some effectiveness, there is a need for new targeted therapies specifically for cervical SCNEC to improve patient prognosis.
Objective: This study aimed to investigate the prognostic significance of tumor size and number of positive pelvic lymph nodes (PLN) in International Federation of Gynecology and Obstetrics (FIGO) 2018 stage IIIC1 cervical cancer patients.
Methods: Clinical data from 626 women with cervical cancer treated at Osaka International Cancer Center in 2010-2020 were retrospectively reviewed. Using the cutoff value obtained on the receiver operating characteristic analysis, the prognostic significance of tumor size and number of positive PLN in stage IIIC1 patients was first evaluated via uni- and multivariate analyses.
Article Synopsis
- * After reviewing 15 studies, the most common chemotherapy regimen used was bleomycin, etoposide, and cisplatin for one to three cycles.
- * Comparisons between NACT and traditional primary surgery showed similar outcomes in response rates, overall survival, and disease-free survival, but more research is needed to determine the best candidates for NACT and optimal cycle numbers.
This study aimed to introduce FD-2, a newly developed anticervical stenosis device for patients with cervical cancer undergoing radical trachelectomy. Using ethylene-vinyl acetate copolymers, we developed FD-2 to prevent uterine cervical stenosis after radical trachelectomy. The tensile test and extractables and leachables testing were performed to evaluate FD-2's safety as a medical device.
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- The study investigates the prevalence and outcomes of pregnancies with abnormal placentas, based on a systematic review of 48 studies conducted from 1974 to 2022.
- It found that babies with a circumvallate placenta faced higher risks of cesarean delivery, preterm birth, and placental abruption, while those with a succenturiate lobe also had increased cesarean rates.
- Overall, the evidence indicates that abnormal placentas are high-risk factors for negative pregnancy outcomes, although more research is needed for definitive conclusions.
Objective: To compare the oncological outcomes between Japanese women who underwent minimally invasive surgery and those who underwent open surgery for early-stage endometrial cancer.
Methods: This population-based retrospective cohort study was conducted using data from the Osaka Cancer Registry from 2011 to 2018. Surgically treated patients for localized (uterine-confined) endometrial cancer were identified.
Article Synopsis
- The study compared the oncological outcomes of Japanese women with uterine-confined, node-negative cervical cancer who had either open surgery or minimally invasive surgery (MIS) between 2011 and 2018.
- A total of 2,279 patients were analyzed, with 225 in the MIS group and 2,054 in the open surgery group, and overall survival rates after four years were similar between both groups (99.5% for MIS vs. 97.2% for open surgery).
- The findings indicate that minimally invasive surgery did not negatively affect survival outcomes compared to traditional open surgery for this type of cancer.
Lacking experience of laparoscopic surgery against gynecologic malignancies, we started performing robot-assisted surgery for uterine cancer in September 2017. Here we compared the safety and efficacy of robot-assisted surgery with those of open surgery in early-stage uterine cancer patients. The surgical time was significantly longer and the blood loss and hospital stay were significantly shorter for robot-assisted versus open surgery.
View Article and Find Full Text PDFIntroduction And Importance: Spontaneous bladder rupture (SBR) is an extremely rare urological emergency. Herein we report a rare case of SBR in a postoperative cervical cancer patient, which was attributable to bladder distension due to a radical hysterectomy-associated neurogenic bladder.
Case Presentation: A 74-year-old nulliparous Japanese patient with cervical cancer (pT1b3N0M0) presented with acute abdominal pain nine days after a radical hysterectomy.
We aimed to evaluate the response to definitive radiotherapy (RT) for cervical cancer based on histological subtypes and investigate prognostic factors in adenocarcinoma (AC). Of the 396 patients treated with definitive RT between January, 2010 and July, 2020, 327 patients met the inclusion criteria, including 275 with squamous cell carcinoma (SCC) and 52 with AC restaged based on the 2018 International Federation of Gynecology and Obstetrics staging system. Patient characteristics, response to RT, and prognoses of SCC and AC were evaluated.
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- Vasa previa is a rare but serious condition during pregnancy, with type II accounting for 21.3% of cases identified in a systematic review of 20 studies from 1998 to 2022.
- The study compared characteristics and outcomes between type I and II vasa previa, finding that rates of assisted reproductive technology, cesarean deliveries, maternal transfusions, and neonatal mortality were similar for both types.
- Additionally, the review indicated associations between assisted reproductive technology and abnormal placenta conditions, although more research is needed for definitive conclusions.
Aim: To investigate the role of lymphadenectomy (LND) in locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy.
Methods: Locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy, with or without LND, were identified. Patients were divided into two groups according to the status of radiologic evidence of lymph node metastasis, and the impact of LND was investigated by evaluating postoperative survival.
Article Synopsis
- In early-stage cervical cancer, ovarian metastasis is uncommon, and transposition of the ovaries during surgery is a standard practice to minimize damage.
- A case study detailed a 45-year-old woman who developed ovarian recurrence after cervical cancer surgery, highlighting the challenges in diagnosis and surgical management of transposed ovaries.
- A systematic review of nine similar cases indicated a poor prognosis for transposed ovarian recurrence, underscoring the need for more research into effective surveillance and surgical strategies for this condition.
Article Synopsis
- Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare condition involving abnormal reproductive and urinary tract development, including a double uterus and one side with a blind vagina and missing kidney.
- A case study highlights a 74-year-old Japanese woman who discovered her HWWS when she experienced postmenopausal vaginal bleeding, leading to the diagnosis of both HWWS and associated cervical cancer.
- After undergoing radical surgery, she was confirmed to have clear cell carcinoma (CCC) of the cervix, and research indicates a higher occurrence of CCC in women with HWWS.
Article Synopsis
- Abnormal cord insertion (ACI) is linked to negative pregnancy outcomes, and this study investigates how ACI relates to assisted reproductive technology (ART) and delivery results among affected women.
- A systematic review analyzed 16 studies published between 1990 and 2021, revealing that ART is associated with higher rates of velamentous cord insertion (VCI) and marginal cord insertion, but the rates for different ART methods were similar.
- Women with VCI were more likely to undergo both elective and emergency cesarean deliveries, indicating that while ART may raise ACI prevalence, more research is needed to confirm this link and address potential confounding factors.
We retrospectively investigated the significance of metastatic lymph nodes in patients with locally recurrent or persistent cervical cancer in a previously irradiated field and subsequently had salvage hysterectomy. Clinical data were obtained from a chart review, and the prognostic impact of the presence, number (1-2 versus ≥3), and location (pelvic versus pelvic plus para-aortic) of lymph node metastasis was investigated by comparing recurrence and survival. In total, 50 patients were included in this study, of which 21 (42.
View Article and Find Full Text PDFBackground: Preoperative anemia affects perioperative outcomes and often causes fatigue and psychological disorders. Therefore, anemia should be treated before a patient undergoes surgery. Ninjin'yoeito (NYT), a Japanese Kampo medicine composed of ginseng and Japanese angelica root with the other 10 herbs, is administered for anemia, fatigue and anxiety; however, there are a few reports that have prospectively examined the effects of NYT before surgery for gynecological diseases.
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- Primary fallopian tube carcinoma (PFTC) shares similarities with ovarian carcinoma, typically spreading to the peritoneal cavity and lymph nodes, but inguinal metastasis is rare.
- A 77-year-old woman presented with a large inguinal tumor, which was found to be a high-grade serous carcinoma originating from the fallopian tube after surgery.
- Following treatment with chemotherapy and maintenance therapy, there has been no recurrence or metastasis reported 9 months post-surgery, and a review of literature identified 14 similar cases, indicating a generally good prognosis for this rare presentation of PFTC.
Although laser vaporization is a popular minimally invasive treatment for cervical intraepithelial neoplasia (CIN), factors influencing CIN recurrence are understudied. Moreover, the effect of surgeon volume on patients' prognosis after laser vaporization for CIN is unknown. This single-center retrospective study evaluated the predictive value of surgeon volume and patient characteristics for laser vaporization outcomes in women with pathologically confirmed CIN2.
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