Publications by authors named "Seiichiro Kojima"

Background And Aim: The use of a hood at the tip of a colonoscope enables aspiration, inversion of the diverticulum, and observation of the inside of the diverticulum. In most previous studies, a short hood was used; however, observation of the diverticulum is often inadequate. Long food is promising by previous research, but it was a retrospective study using propensity matching and has some limitations.

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  • The study aimed to explore the relationship between pancreatic cysts and cystic diseases in other organs using abdominal ultrasonography among patients undergoing medical checkups.
  • Out of 4,496 patients examined, 172 had pancreatic cysts, while many others had liver and renal cysts, highlighting the prevalence of these conditions.
  • The findings indicated that pancreatic cysts were more common in females, and the presence of renal cysts may suggest a potential link, indicating the need to monitor for pancreatic cysts if renal cysts are found.
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We report a case of successful treatment of stomal variceal bleeding with percutaneous transhepatic obliteration using a microballoon catheter concomitantly with drainage vein compression. A 72-year-old man with alcoholic cirrhosis was admitted to our hospital due to repeated hemorrhage of stomal varices. Percutaneous transhepatic obliteration was then selected for treatment because computed tomography revealed the stomal varices being fed by only two branches of the superior and inferior mesenteric veins.

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Objectives: We investigated whether there is a difference in the frequency of comorbidity between patients with pancreatic cysts and those without pancreatic cysts by abdominal ultrasonography in patients undergoing medical checkup screening.

Methods: The subjects were 6,627 patients who underwent abdominal ultrasonography at Tokai University Hachioji Hospital's Health Screening Center between April 2019 and March 2020.

Results: Of the total 6,627 patients, 158 (2.

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  • Patients with inflammatory bowel disease (IBD), specifically those with ulcerative colitis (UC) and Crohn's disease (CD), frequently experience oral health issues like periodontitis, yet its impact on gut inflammation is poorly understood.
  • A study involving 60 IBD patients and 45 healthy controls revealed that the gut microbiome of IBD patients was more similar to their oral microbiome, indicating an increased colonization of gut bacteria by oral bacteria.
  • While early periodontitis didn't significantly alter clinical outcomes for most IBD patients, it was associated with a worsening activity index in some CD patients, suggesting it could exacerbate symptoms in certain cases.
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  • A 60-year-old man with persistent fever and abdominal pain was diagnosed with acute cholecystitis and later transferred for further evaluation, revealing high eosinophil levels and inflammation of the gallbladder.
  • He was treated successfully with endoscopic gallbladder drainage and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), receiving corticosteroids and immunosuppressants, which helped reduce his eosinophil count and relieved symptoms.
  • However, 6 months post-discharge, he experienced a cerebral hemorrhage, demonstrating the complex nature of EGPA, which can present with various symptoms, including cholecystitis.
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Background: We aimed to elucidate the characteristics and prognosis of autoimmune hepatitis (AIH) patients with immunoglobulin (Ig) G4-positive plasma cell infiltration.

Methods: We enrolled 84 AIH patients. The number of IgG- and IgG4-positive plasma cells was immunohistochemically counted per high-power field in the portal area.

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A 71-year-old woman presented to a nearby hospital with an occipital scalp ulcer with exudate. Thoracoabdominal enhanced computed tomography (CT) was performed due to suspected cancer. The imaging results showed tumors in the pancreatic tail and at multiple sites in the lung, whereupon she was referred to our hospital for further investigation.

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  • * EUS-FNA (Endoscopic Ultrasound Fine Needle Aspiration) was conducted on tumors in the pancreatic head and body, retrieving cells that indicated cancer.
  • * A total pancreatectomy was performed, revealing four lesions, with histological analysis confirming the same type of cancer in both the pancreatic cyst and the tumors.
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We reported the case of a 50-year-old man diagnosed with extrinsic NK/T-cell lymphoma. He was initially diagnosed with locally advanced unresected pancreatic duct carcinoma and was treated with combination chemotherapy using gemcitabine and nabpaclitaxel. One month after treatment, he developed bleeding.

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Aim: To investigate the current status of portal vein thrombosis (PVT) in Japan, the Clinical Research Committee of the Japan Society of Portal Hypertension undertook a questionnaire survey.

Methods: A questionnaire survey of 539 cases of PVT over the previous 10 years was carried out at institutions affiliated with the Board of Trustees of the Japan Society of Portal Hypertension.

Results: The most frequent underlying etiology of PVT was liver cirrhosis in 75.

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  • The study aimed to assess the safety and feasibility of repeating transarterial chemoembolization (TACE) using a miriplatin-lipiodol suspension for treating patients with hepatocellular carcinoma (HCC).
  • Sixteen patients were analyzed, with the study measuring the total doses of miriplatin, lipiodol, and other materials used, along with any adverse events during their first and last TACE sessions.
  • Results showed an average of 3.7 TACE sessions per patient without significant differences in adverse effects between the first and last procedures, concluding that repeated TACE with this method is both safe and feasible for selected patients.
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We here present a case involving a complicated type of gastric fundal varices treated by balloon-occluded retrograde transvenous obliteration. A newly developed 1.8-Fr tip coaxial microballoon catheter was successfully advanced into narrow and tortuous varices, and a sclerosant could be infused in a reasonable manner, avoiding reflux into collaterals.

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A 64-year-old woman treated for anemia and ascites exhibited hepatic encephalopathy. Abdominal ultrasonography and computed tomography (CT) showed communication between the portal vein and the middle hepatic vein, indicating an intrahepatic portosystemic venous shunt (PSS). Since hepatic encephalopathy of the patient was resistant to medical treatment, interventional radiology was performed for the treatment of shunt obliteration.

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A survey of 21,493 patients who visited our Health Check-up Center during the 6-year period from 2005 to 2010 was conducted for the endpoints of drinking situation and various lifestyle-related diseases. Males accounted for 57.2% (mean age: 53.

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Objective: To evaluate balloon-occluded arterial stump pressure (BOASP), which is responsible for effective balloon-occluded transarterial chemoembolization (B-TACE), at each hepatic arterial level before B-TACE using a 1.8-French tip microballoon catheter for unresectable hepatocellular carcinoma (HCC).

Material And Methods: The BOASP at various embolization portions was retrospectively investigated.

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We present a case of adrenal rest tumor of the liver in which differential diagnosis from lipid rich-hepatocellular carcinoma (HCC) was challenging. The patient was a 50-year-old woman in whom a 3-cm tumorous mass was discovered in segment 7 of the liver during computed tomography evaluation of a uterine leiomyoma. The preoperative diagnosis was HCC, and subsegmental liver resection was performed.

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Objective: To evaluate the technical feasibility and safety considerations of balloon-occluded transarterial chemoembolization (B-TACE) using a newly developed 1.8-French (Fr) tip microballoon catheter for hepatocellular carcinoma (HCC).

Material And Methods: Between February 2013 and May 2013, 31 patients (20 males, 11 females; age range 56-85 years) underwent B-TACE using a 1.

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We investigated the outcome of the patients with alcoholic liver cirrhosis who had visited our hospital from 2007 to 2013. We compared them with the patients with type C liver cirrhosis, matched in gender and in age. The patients with alcoholic liver cirrhosis who dropped out accounted for 19.

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The patient, a 69-year-old man, had a chief complaint of hepatomegaly. The liver was palpated four fingerbreadths below the costal margin, and the spleen was three fingerbreadths below the costal margin. There were no other abnormal findings.

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Aim: In this multicenter, randomized trial, we evaluated the effectiveness of meloxicam - a non-steroidal anti-inflammatory drug - as an adjuvant for enhancing antiviral efficacy and preventing neutropenia during the treatment of patients with genotype 1 chronic hepatitis C using peginterferon and ribavirin.

Methods: A total of 60 patients were randomly assigned, in a 1:1 ratio, to either the meloxicam or the control group after stratification by neutrophil count. Both groups received weekly peginterferon-α-2a (180 μg) and a weight-based dose of ribavirin for 48 weeks.

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A 47-year-old female patient with type C liver cirrhosis underwent endoscopic injection sclerotherapy for esophageal varices 13 years ago. The patient had no past history of hysterectomy or any other gynecological disorders. She was admitted to our hospital because of persistent vaginal bleeding and exacerbation of anemia.

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Fatty liver and male gonadal dysfunction are potential late effects of therapy in adult survivors treated with stem cell transplantation (SCT) in childhood. Obesity and metabolic syndrome also are associated with low serum testosterone levels in the general population. However, the relationship between the degree of fatty liver and changes in serum testosterone levels in adult survivors has not been fully studied.

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Aim:   The optimal ribavirin dose in the treatment of patients infected with hepatitis C virus (HCV) genotype 2 remains to be elucidated. We aimed to seek the optimal ribavirin dose required for this genotype in a randomized trial.

Methods:   We compared the efficacy and tolerability of the 24-week peginterferon α-2b (1.

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