Implantation of amniotic membrane as a vascular substitute in the external jugular vein of juvenile sheep.

Objective: Amniotic membrane, as a natural biomaterial, has many advantages, such as low immunogenicity, anti-inflammation, antifibrosis, and rich extracellular matrix components, which make it a promising source for vascular tissue engineering. This study assessed the feasibility of constructing a vein conduit from the amniotic membrane and implanting it in the external jugular vein of juvenile sheep.

Methods: Human amniotic membrane was prepared using fresh human placenta.