Publications by authors named "Seia Urata"
The crystal structure of the tetrameric human vasohibin-1-SVBP complex reveals a variable arm region within the structural core.
Acta Crystallogr D Struct Biol
October 2020
Article Synopsis
- Vasohibins play a crucial role in regulating processes like angiogenesis, tumor growth, and neuronal differentiation through their interaction with the small vasohibin-binding protein (SVBP).
- Recent studies, including crystal structure determinations, have revealed insights into the complex's formation and function, but the regulatory mechanisms remain unclear.
- This research specifically highlights the discovery of a novel domain-swapped heterotetramer structure that may influence enzyme activity due to the stabilization provided by conserved residues and differences in molecular dynamics compared to simpler structures.