Publications by authors named "Sei Won Lee"
: Exposure to particulate matter <2.5 μm (PM) is linked to chronic obstructive pulmonary disease (COPD), but most studies lack individual PM measurements. Seasonal variation and their impact on clinical outcomes remain understudied.
View Article and Find Full Text PDFBody mass index (BMI) is associated with chronic obstructive pulmonary disease (COPD) risk. We investigated the association between BMI and the risk of COPD among young individuals. Using the Korean National Health Information Database, we screened individuals aged 20-39 years who participated in the national health examination between 2009 and 2012.
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- Diabetes mellitus (DM) and alcohol consumption are both risk factors for tuberculosis (TB), prompting a study on their relationship specifically in individuals with type 2 DM (T2DM).
- The study followed over 2.4 million T2DM patients from 2009 to 2018, identifying the effects of alcohol consumption on TB development, with findings categorized into non-drinkers, mild-to-moderate drinkers, and heavy drinkers.
- Results indicated that mild-to-moderate drinkers had a lowered risk of TB, while heavy drinkers showed an increased risk, especially those consuming 20 g/day or more; additionally, current smokers also faced heightened risks, making the relationship complex.
Article Synopsis
- * Results showed that individuals with MetS had a higher risk of COPD, with specific components such as abdominal obesity, hypertension, and low HDL cholesterol being significantly associated with increased risk.
- * The findings indicate that as the number of MetS components increases, so does the risk of developing COPD, highlighting the importance of monitoring young individuals with MetS for potential respiratory issues.
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- - The study investigates the relationship between the COPD Assessment Test (CAT) scores and postoperative pulmonary complications (PPCs) in patients with mild to moderate COPD undergoing lung surgery, highlighting the necessity of thorough preoperative evaluations.
- - Out of 83 patients analyzed, 19.2% experienced PPCs, with a notable correlation found between higher CAT scores and increased risk of complications; specifically, a CAT score of ≥7 was identified as a significant predictor.
- - The findings suggest that CAT scores can serve as an effective tool for predicting the likelihood of PPCs in COPD patients prior to lung resection surgery, outperforming other traditional predictive factors in this context.
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- * Sputum samples from 102 COPD patients were analyzed over a year, revealing that lower PM exposure correlates with higher microbial diversity, especially in spring.
- * Results indicate significant seasonal variations in airway microbiome composition, particularly pronounced in patients with moderate COPD, suggesting that PM exposure can alter respiratory microbiota based on both exposure levels and seasons.
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- * Research reveals that a specific type of macrophage, CD39CD9 interstitial macrophages (IMs), is inhibited by IL-23 but increases when treated with an IL-23 inhibitor, showing potential for managing NDA.
- * CD39CD9 IMs help reduce neutrophil extracellular trap formation and suppress inflammatory responses, indicating their significance as a therapeutic target for treating IL-23-Th17-mediated asthma.
Although smoking is an established risk factor for Mycobacterial infection, the association between smoking and nontuberculous mycobacterial pulmonary disease (NTM-PD) remains unclear. We evaluated the association between smoking and NTM-PD and tuberculosis (TB) using a population-based South Korean nationwide cohort. Using the Korean National Health Insurance Database, we screened individuals over 20 years of age who underwent the national health screening program in 2009.
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- This study investigates how exposure to particulate matter (PM), particularly those smaller than 2.5 µm, is linked to changes in DNA methylation within certain gene regions (CpG islands) in patients with chronic obstructive pulmonary disease (COPD).
- A total of 95 male COPD patients were monitored over a year for PM exposure, and their blood samples were analyzed to identify specific changes in DNA methylation related to these exposures.
- Results indicated a significant number of differential methylated CpG sites, with notable genes involved in processes relevant to neurodegenerative diseases and cancer linked to PM exposure.
Background: Low socioeconomic status is a risk factor for chronic obstructive pulmonary disease (COPD); however, the association between low household income and COPD in young populations remains unclear.
Methods: We screened individuals aged 20-39 years who underwent the national health examination between 2009 and 2012 using the Korean National Health Information Database, which was searched until December 2019. We identified 5 965 366 eligible individuals, and 13 296 had newly developed COPD based on health insurance claims.
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- This study examined how different chemical elements in particulate matter (PM 2.5) affect respiratory health in COPD patients and how their living conditions and daily habits play a role.
- Data was collected from 89 male COPD patients in South Korea, analyzing 18 metallic elements using advanced spectroscopy techniques and comprehensive questionnaires about their lifestyles.
- Key findings revealed that certain elements like titanium and aluminum were linked to respiratory health, while factors like good ventilation and air purifier use helped reduce harmful element concentrations, suggesting potential for personalized treatment strategies.
Article Synopsis
- - The study investigates how exposure to both cigarette smoke and fine particulate matter (PM) affects patients with chronic obstructive pulmonary disease (COPD) and looks at similar effects in mice and human lung cells.
- - Findings show that higher ambient PM levels are linked to worse COPD symptoms and increased lung damage, inflammation, and cell death in mice exposed to both smoke and PM.
- - The research suggests that PM exacerbates smoking-related lung inflammation and cell death through a process called pyroptosis, indicating it can worsen quality of life in smoking COPD patients.
The application of microbiome-based therapies in various areas of human disease has recently increased. In chronic respiratory disease, microbiome-based clinical applications are considered compelling options due to the limitations of current treatments. The lung microbiome is ecologically dynamic and affected by various conditions, and dysbiosis is associated with disease severity, exacerbation, and phenotype as well as with chronic respiratory disease endotype.
View Article and Find Full Text PDFBackground: Endobronchial valve (EBV) therapy, a validated method for bronchoscopic lung volume reduction (BLVR) in severe emphysema, has been explored for persistent air-leak (PAL) management. However, its effectiveness and safety in the Asian population require further real-world evaluation. In this study, we assessed the outcomes of treatment with EBV within this demographic.
View Article and Find Full Text PDFBackground: Most reports of pulmonary manifestations in rheumatoid arthritis (RA) have been related to interstitial lung diseases. RA and COPD are both chronic inflammatory systemic diseases.
Research Question: Does RA increase the risk of developing COPD? Is there a difference between seropositive and seronegative RA in the risk of COPD?
Study Design And Methods: Using the Korean National Health Insurance Database, we screened individuals diagnosed with RA between 2010 and 2017.
Rapid and accurate identification of the bacteria responsible for sepsis is paramount for effective patient care. Molecular diagnostic methods, such as polymerase chain reaction (PCR), encounter challenges in sepsis due to inhibitory compounds in the blood, necessitating their removal for precise analysis. In this study we present an innovative approach that utilizes vancomycin (Van) and allantoin (Al)-conjugated polydopamine (PDA)-coated magnetic nanoparticles (MNPs) for the rapid and automated enrichment of bacteria and their DNA extraction from blood without inducing clumping and aggregation of blood.
View Article and Find Full Text PDFRehabilitation improves symptoms, quality of life, and survival in patients with chronic respiratory or cardiovascular disease. We evaluated smartphone application-based rehabilitation programs for patients with chronic respiratory or cardiovascular diseases. This was a single-center prospective single arm study.
View Article and Find Full Text PDFBackground: Viral infection is a risk factor for asthma exacerbation (AE). However, bacterial infections related to AE in adults are poorly known. On the other hand, obese patients with asthma have their own clinical and biological characteristics compared with non-obese patients.
View Article and Find Full Text PDFPositive Airway Pressure Therapy Compliance in Patients With Comorbid Insomnia and Sleep Apnea.
Clin Exp Otorhinolaryngol
May 2024
Objectives: This study aimed to compare positive airway pressure (PAP) therapy compliance between patients with comorbid insomnia and sleep apnea (COMISA) and those with obstructive sleep apnea (OSA) alone. It also assessed the influence of insomnia clinic visits on PAP compliance.
Methods: Patients diagnosed with OSA and initiated on PAP therapy between January 2012 and December 2021 were included.
Background: Pulmonary rehabilitation is well known to improve clinical symptoms (including dyspnea), quality of life, and exercise capacity in patients with chronic obstructive pulmonary disease (COPD). However, researchers have reported difficulties in practicing center-based pulmonary rehabilitation. Recently, mobile app-based pulmonary rehabilitation has become available in clinical practice.
View Article and Find Full Text PDFCOPD Risk Factor Profiles in General Population and Referred Patients: Potential Etiotypes.
Int J Chron Obstruct Pulmon Dis
November 2023
Article Synopsis
- The study aimed to identify the risk factors for chronic obstructive pulmonary disease (COPD) in both a general population and referred COPD patients, utilizing data from two distinct datasets.
- Findings showed that the mean age of COPD patients was 67 years, with notable differences in gender distribution and forced expiratory volume between participants from the general population and referral clinics.
- Key risk factors identified included cigarette smoking, infections, pollution, and asthma, with significant variations in prevalence between the datasets, highlighting a need to investigate unidentified risk factors in the general population.
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- Fine particulate matter (PM) is linked to worsening outcomes in chronic obstructive pulmonary disease (COPD), but there's little guidance on how to reduce its effects through personal behavior.
- A study tested a behavioral intervention on a group of COPD patients, comparing those who received the intervention with those who just received standard care over nine months.
- Results showed that the intervention group had significant improvements in COPD-related health scores, especially among those who adhered well to the intervention, highlighting the potential effectiveness of behavioral strategies in managing PM exposure.
Superoxide dismutase (SOD) can convert active oxygen to oxygen or hydrogen peroxide, and recent research has suggested that it can protect against lung damage and fibrosis. Clinical applications based on SOD remain limited however due to costs and low stability. We here investigated a potential new therapeutic delivery system for this enzyme in the form of SOD-overexpressing Bacillus amyloliquefaciens spores which we introduced into a bleomycin-induced pulmonary fibrosis mouse model.
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