Age-dependent changes in CT vertebral attenuation values in opportunistic screening for osteoporosis: a nationwide multi-center study.

Objectives: To examine how vertebral attenuation changes with aging, and to establish age-adjusted CT attenuation value cutoffs for diagnosing osteoporosis.

Materials And Methods: This multi-center retrospective study included 11,246 patients (mean age ± standard deviation, 50 ± 13 years; 7139 men) who underwent CT and dual-energy X-ray absorptiometry (DXA) in six health-screening centers between 2022 and 2023. Using deep-learning-based software, attenuation values of L1 vertebral bodies were measured.

Regions of interest in opportunistic computed tomography-based screening for osteoporosis: impact on short-term in vivo precision.

Objective: To determine an optimal region of interest (ROI) for opportunistic screening of osteoporosis in terms of short-term in vivo diagnostic precision.

Materials And Methods: We included patients who underwent two CT scans and one dual-energy X-ray absorptiometry scan within a month in 2022. Deep-learning software automatically measured the attenuation in L1 using 54 ROIs (three slice thicknesses × six shapes × three intravertebral levels).