Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis.

Background: Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP). While the large-scale mitochondrial release of pro-apoptotic proteins activates caspase-dependent cell death, a limited release results in sub-lethal caspase activation which promotes tumorigenesis.

Error-driven global transition in a competitive population on a network.

We show, both analytically and numerically, that erroneous data transmission generates a global transition within a competitive population playing the "Minority Game" on a network. This transition, which resembles a phase transition, is driven by a "temporal symmetry breaking" in the global outcome series. The phase boundary, which is a function of the network connectivity p and the error probability q, is described quantitatively by the crowd-anticrowd theory.