Publications by authors named "Sehweil Salah M M"
Article Synopsis
- - Gap junctions are channels that allow communication between adjacent cells, but their role in brain tumors, particularly glioblastoma multiforme (GBM), is not well understood.
- - Research shows that the protein Connexin 43 (Cx43) and the polyamine spermine are co-expressed in human GBM samples, implying they might work together in tumor development and integration into surrounding neural networks.
- - The study utilized various microscopy techniques to demonstrate that Cx43 and spermine localize in specific regions of GBM, indicating that they may facilitate gap junction activity, which could enable tumor cells to share metabolic products with neighboring cells.
Article Synopsis
- - Connexin 43 (Cx43) is a multifunctional protein important for gap junction communication and is thought to influence the behavior of anaplastic astrocytomas during tumor growth through mechanisms like neuroinflammation and oxygen-glucose deprivation.
- - Researchers studied Cx43 localization and gap junction ultrastructure in malignant brain tumors by using confocal laser microscopy and electron microscopy on tumor samples, specifically looking at the interactions between Cx43 and GFAP (a glial protein).
- - Their findings showed that Cx43 was prominently present in the tumor cells, indicating many gap junctions and suggesting that these connections might facilitate communication and metabolic exchange between glioma cells, potentially aiding in tumor progression.
Article Synopsis
- Malignant ischemic infarction, a severe ischemic stroke affecting the middle cerebral artery, leads to dangerous postischemic edema that can cause brain herniation and death.
- The surgical procedure known as decompressive hemicraniectomy involves removing a large portion of the skull to relieve pressure and allows better access to critical areas of the brain.
- Combining this surgery with the resection of the temporal pole and tentoriotomy has been shown to effectively reduce mortality rates in patients suffering from this type of stroke.
The phenomenon of unstable expression of gap junction's proteins connexins remains a "visiting card" of astrocytic tumors with various degrees of malignancy. At the same time, it stays unclear what is detected by the positive expression of connexins in astrocytic tumors: gap junctions, hemi-channels, or connexin proteins in cytosol. In the present work, for the first time, we demonstrate an ultrastructural evidence of gap junctions in pleomorphic xanthoastrocytoma, a rare primary brain tumor, the intercellular characteristics of which are poorly studied and remain very discursive and controversial.
View Article and Find Full Text PDF