Publications by authors named "Sehrish Basheer"
Background: Ang-(1-7) (angiotensin (1-7)) via MasR (Mas receptor) opposes vaso-injurious actions of Ang II (angiotensin II) as shown in models of pulmonary hypertension. The underlying mechanisms remain unclear. We hypothesized cross talk between Ang-(1-7) and the protective arm of the ET-1 (endothelin-1) system involving MasR and ETR (endothelin receptor type B).
View Article and Find Full Text PDFEnalapril is an orally administered angiotensin-converting enzyme inhibitor which is widely prescribed to treat hypertension, chronic kidney disease, and heart failure. It is an ester prodrug that needs to be activated by carboxylesterase 1 (CES1). CES1 is a hepatic hydrolase that in vivo biotransforms enalapril to its active form enalaprilat in order to produce its desired pharmacological impact.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how different Pakistani dietary fats affect metabolic and cardiovascular health by observing the effects on four groups of mice over 16 weeks.
- Mice on high-fat diets (HFD) gained more weight, with blood tests showing increased glucose and cholesterol levels, particularly in those consuming banaspati ghee (HFD-BG).
- Histological analysis revealed that mice on HFD-BG and plant oil (HFD-O) had more lipid accumulation in their livers than those on desi ghee (HFD-DG) and the control group (C-ND).