Clinicopathologic description of a cutaneous melanocytic tumor in a 1-year-old cat.

A feline cutaneous melanocytic tumor in a 1-year-old cat is reported. The cytologic, histologic, and immunohistochemical characteristics of the pediatric feline cutaneous melanocytoma are included. A solitary, black-colored nodule on the head was histologically diagnosed as the epithelioid type of melanocytoma.

Evaluation of users' level of satisfaction for an artificial intelligence-based diagnostic program in pediatric rare genetic diseases.

The artificial intelligence (AI)-based genetic diagnostic program has been applied to genome sequencing to facilitate the diagnostic process. The objective of the current study was to evaluate the experience and level of satisfaction of participants using an AI-based diagnostic program for rare pediatric genetic diseases. The patients with neurodevelopmental disorders or hearing impairments, their guardians, and their physicians from 16 tertiary general hospitals were enrolled.

Evaluation of Road Transport Pollutant Emissions from Transporting Building Materials to the Construction Site by Replacing Old Vehicles.

Since the life cycle of a building spans more than 50 years, studies of the environmental impacts in the construction industry have focused on reducing the energy consumption and greenhouse gas emissions during the operation and maintenance phase. The products of the construction industry are assembled using various building materials manufactured outside of the construction site. Consequently, it is essential that the manufactured building materials be transported to the construction site using various types of transportation methods.

The smoking paradox: exploring why attitudes toward cigarette smoking are a weak predictor of cigarette smoking.

Objective: An attitude change perspective represents a central line of research in the smoking literature. This line of research focuses on influencing individuals' attitudes toward smoking in order to alleviate the negative outcomes of smoking and to achieve positive smoking behaviours. This line of research, however, does not explain why attitudes toward cigarette smoking are a weak predictor of cigarette smoking, an indication of a smoking paradox.

Physical activity and self-rated health: role of contexts.

The purpose of this study is to examine how much variance in self-rated health is attributable to household and administrative-area levels. Additionally, the study investigates the association between physical activity and self-rated health while adjusting for various covariates at the individual, household, and district levels in Seoul, South Korea. A cross-sectional study of the 2009 Seoul Welfare Panel Study conducted by Seoul Welfare Foundation was utilized.

Does Organization Matter for Health? The Association Between Workplace Social Capital and Self-Rated Health.

Objective: This study aimed to investigate the association between workplace social capital at the individual and government organizational levels, and self-rated health among public employees in South Korea.

Methods: We conducted a cross-sectional survey of public employees at government organizations in South Korea from June 2018 to December 2018. In total, 815 respondents in 31 government organizations were analyzed.

Social capital and perceived stress: The role of social context.

Background: The aim of this study is twofold: to investigate how much variance in individual perceived stress is attributed to household and area levels, respectively, and to examine the association between social capital at the individual, household, and area levels and perceived stress, while adjusting for various cofounders at the individual, household, and area levels.

Methods: This study used data from the 2010 Seoul Welfare Panel Study conducted by the Seoul Welfare Foundation. A total sample of 5881 individuals in 2820 households within 25 areas was used for multilevel analysis.

Multi-laboratory evaluation of 1,3-propane sultone, N-propyl-N-nitrosourea, and mitomycin C in the Pig-a mutation assay in vivo.

The mutagenic potencies of 1,3-propane sultone (PS), N-propyl-N-nitrosourea (PNU), and mitomycin C (MMC) were investigated in three independent laboratories in Korea using the Pig-a assay in vivo. Sprague-Dawley rats were treated with vehicle or test substance on three consecutive days. Blood samples were collected for measuring Pig-a mutant phenotypes (CD59-deficient erythrocytes, RBC; CD59-deficient reticulocytes, RET) on days -1, 15, and 29 after the first treatment.

A Delta Neutrophil Index for the Prediction of Contrast-Induced Nephropathy in Patients With St-Elevation Myocardial Infarction Followed By Percutaneous Coronary Intervention.

Purpose: We assessed the usefulness of the delta neutrophil index (DNI), reflecting immature granulocytes, to stratify risk for developing contrast-induced nephropathy (CIN) in patients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) in a clinical setting.

Methods: This study retrospectively analyzed prospective data of eligible adult patients admitted to the emergency department (ED) with STEMI followed by PCI. We determined DNI at multiple time points and analyzed the development of CIN and in-hospital mortality according to CIN incidence.

The impact of extracurricular activities participation on youth delinquent behaviors: An instrumental variables approach.

The purpose of this study was to examine the association between extracurricular activities (EA) participation and youth delinquency while tackling an endogeneity problem of EA participation. Using survey data of 12th graders in South Korea (n = 1943), this study employed an instrumental variables approach to address the self-selection problem of EA participation as the data for this study was based on an observational study design. We found a positive association between EA participation and youth delinquency based on conventional regression analysis.

Association between perfluorinated compound concentrations in cord serum and birth weight using multiple regression models.

The effects of exposure to the perfluoroalkyl and polyfluoroalkyl substances (PFASs) perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) on birth weight have been examined in several studies, but other PFASs have not been considered. We conducted a cross-sectional survey of newborns in Seoul, South Korea, collecting 118 serum samples, for 85 of which we had a full range of information. We conducted multiple regression analyses to examine the association between nine PFAS concentrations in cord serum and birth weight.

Longitudinal association between social capital and self-esteem: a matter of context.

The aim of this study is to investigate the longitudinal association between indicators of different components of social capital at the individual, household, and area levels and self-esteem while adjusting for various confounders at multiple levels. Respondents participating in Wave 1 (2009) and 2 (2010) of the Seoul Welfare Panel Study were used in the analysis. The final sample for the current study includes a total of 5127 participants in 2738 households within 25 administrative areas.

Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy.

Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes.

Social capital and depression: does household context matter?

The purpose of this study is 2-fold: (1) to examine how much variance of depression is attributed to the household level and (2) to examine the relationships between individual- and household-level social capital and depression using multilevel analysis from the Korean Welfare Panel Study data. Results show that more than 30% of variance in depression is derived from household-level differences. Results also show that individual level of trust and satisfaction with relationships in the family and household level of satisfaction with relationships among family members was related to depression.

Compositional and contextual associations of social capital and self-rated health in Seoul, South Korea: a multilevel analysis of longitudinal evidence.

This study aims to examine the association between social capital at the individual and administrative-area levels and individual self-rated health while adjusting for various confounders at multiple levels using a multilevel analysis with longitudinal data from Seoul, South Korea. Respondents participating in Wave 1 (2009) and 2 (2010) of the Seoul Welfare Panel Study who have full information on the independent and dependent variables were used in the final analysis. This yielded a total of 5482 participants in 2742 households, which were in turn found within 25 administrative areas in Seoul, South Korea.

Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.

Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment.

Individual, household and administrative area levels of social capital and their associations with mental health: a multi-level analysis of cross-sectional evidence.

Background: Research has seldom considered social capital at the individual, household and administrative area level simultaneously and examined its association with mental health.

Aim: The main purpose of this study was to examine the association between social capital and mental health while controlling for various confounders at multiple levels using multi-level analysis and operationalizing social capital at the individual, household and administrative area level.

Methods: This study used cross-sectional data from the 2010 Seoul Welfare Panel Study conducted by the Seoul Welfare Foundation (participation rates for the household and household members were 87.

A multilevel analysis of social capital and self-reported health: evidence from Seoul, South Korea.

Background: This study aims to resolve two limitations of previous studies. First, as only a few studies examining social capital have been conducted in non-western countries, it is inconclusive that the concept, which has been developed in Western societies, applies similarly to an Asian context. Second, this study considers social capital at the individual-level, area-level and cross-levels of interaction and examines its associations with health while simultaneously controlling for various confounders at both the individual-level and area-level, whereas previous studies only considered one of the two levels.

Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models.

To explore effects of Forsythia koreana methanol extract (FKME) on mast cell-mediated allergic and inflammatory properties, the effect of FKME was evaluated on compound 48/80-induced systemic anaphylaxis, ear swelling, and anti-dinitrophenyl (DNP) immunoglobulin E (IgE)-induced passive cutaneous anaphylaxis (PCA). In addition, the effect of FKME was investigated on the histamine release from rat peritoneal mast cells (RPMCs) stimulated by compound 48/80, which promotes histamine release. The human mast cell line HMC-1 was stimulated by phorbol 12-myristate 13-acetate plus calcium ionophore A23187.