Publications by authors named "Seham M Alqahtani"
Diabetes mellitus (DM) is a metabolic complication and can pose a serious challenge to human health. DM is the main cause of many life-threatening diseases. Researchers of natural products have been continuously engaged in treating vital diseases in an economical and efficient way.
View Article and Find Full Text PDFDiabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of the pancreas manifested as a decline in the insulin production or the tissue's resistance to the insulin. In this research, we have rationally designed and synthesized new succinimide-thiazolidinedione hybrids for the management of DM. In a multistep reaction, we were able to synthesize five new derivatives ().
View Article and Find Full Text PDFArticle Synopsis
- Diabetes mellitus is a major global health issue, prompting research to find antidiabetic bioactive compounds from specific plant sources.
- Various plant extracts were tested in laboratory assays for their ability to inhibit enzymes related to glucose metabolism, finding ethyl acetate to be the most effective fraction.
- Two promising compounds were isolated and characterized, demonstrating strong inhibitory effects on α-glucosidase and α-amylase, potentially paving the way for further animal studies on their antidiabetic properties.