Publications by authors named "Seggewiss H"
Article Synopsis
- The study investigates the link between arterial hypertension (HTN) and markers of left ventricular dysfunction and inflammation in patients with hypertrophic cardiomyopathy (HCM).
- It compares 30 HCM patients with HTN to 30 without, assessing echocardiographic measures and inflammatory markers.
- Results reveal that while both groups had similar cardiac function, those with HTN showed higher levels of systemic inflammation, suggesting HTN's negative effects on HCM patients stem from overall body inflammation rather than direct heart function decline.
Aims: Myocardial work (MyW) is an echocardiographically derived parameter to estimate myocardial performance. The calculation of MyW utilizes pressure strain loops from global longitudinal strain and brachial blood pressure (BP) as a surrogate of left ventricular systolic pressure (LVSP). Since LVSP cannot be equated with BP in hypertrophic obstructive cardiomyopathy (HOCM), we explored whether LVSP can be derived non-invasively by combining Doppler gradients and BP.
View Article and Find Full Text PDFBackground: The current ACC/AHA guidelines on hypertrophic cardiomyopathy (HCM) caution that alcohol septal ablation (ASA) might be less effective in patients with left ventricular outflow tract obstruction (LVOTO) ≥ 100 mm Hg.
Methods: We used a multinational registry to evaluate the outcome of ASA patients according to baseline LVOTO.
Results: A total of 1346 ASA patients were enrolled and followed for 5.
Aims: Echocardiographic diagnosis of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) often requires extensive provocative manoeuvers. We investigated, whether echocardiography-derived parameters obtained at rest can aid to determine the presence of LVOTO in persons with HCM.
Methods And Results: Consecutive patients with HCM admitted to a referral centre underwent standardized transthoracic echocardiographic examination including provocative manoeuvers.
Article Synopsis
- Atrioventricular block is a common complication following alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy, leading to some requiring a permanent pacemaker (PPM).
- In a study involving 1,814 patients using the Euro-ASA registry, 9.4% underwent PPM implantation within 30 days after the procedure, with a follow-up averaging 4 years.
- Long-term outcomes revealed that while survival and functional class were similar between groups, those with PPM had a lower left ventricular outflow gradient and lower likelihood of needing further interventions.
Article Synopsis
- A new risk score called ASA-SCARRE was developed to assess the risk of sudden cardiac arrest in patients with hypertrophic obstructive cardiomyopathy after alcohol septal ablation.
- The study analyzed over 1,800 patients and found that independent predictors of sudden cardiac arrest included septum thickness and left ventricular outflow tract gradient.
- The ASA-SCARRE scores ranged from 0 to 2 based on these two factors, providing a simple method to predict long-term risk of cardiac events post-treatment.
Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry.
Methods And Results: 1739 patients with HCM were studied.
Aims: Since its introduction, alcohol septal ablation (PTSMA) was discussed as treatment option only in elderly symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). We report on long-term follow-up after PTSMA with respect to patient's age.
Methods And Results: Between May 2000 and June 2017, we treated 952 consecutive HOCM patients with PTSMA; 133 (14.
Purpose Of Review: Patients with hypertrophic cardiomyopathy (HCM) who have left ventricular outflow tract obstruction (LVOTO) often experience severe symptoms and functional limitation. Relief of LVOTO can be achieved by two invasive interventions, i.e.
View Article and Find Full Text PDFBackground: The aim of this study was to evaluate short- and long-term outcomes related to dose of alcohol administered during alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM). Current guidelines recommend using 1-3 mL of alcohol administered in the target septal perforator artery, but this recommendation is based more on practical experience of interventionalists rather than on systematic evidence.
Methods: We included 1448 patients and used propensity score to match patients who received a low-dose (1.
Introduction: Sex-related differences in diagnosis and treatment of hypertrophic obstructive cardiomyopathy (HOCM) are still unclear. Therefore, we analyzed baseline characteristics of symptomatic patients with indication for alcohol septal ablation (PTSMA) with respect to gender.
Methods And Results: Between 05/2000 and 06/2017 indication for PTSMA was seen in 1014 patients (420 (41.
Hypertrophic cardiomyopathy is the most common genetically determined cardiac disease with a prevalence of 0.2-0.6%.
View Article and Find Full Text PDFPatients with hypertrophic cardiomyopathy (HCM) exhibit a variable phenotype with ventricular hypertrophy as the cardinal manifestation and left ventricular (LV) outflow tract obstruction (LVOTO) as a key pathophysiologic determinant. Patients with severe LVOTO usually present with exertional dyspnea, exertional syncope, and heart failure symptoms, while successful relief of LVOTO by pharmacological or invasive interventions leads to a dramatic improvement in clinical status. Proper management of obstructive HCM remains challenging and poses numerous clinical dilemmas.
View Article and Find Full Text PDFObjective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement.
Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with ≥30 mm Hg treated using ASA in nine European centres.
Aims: Based on European guidelines, alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) is indicated only in patients with interventricular septum (IVS) thickness >16 mm. The aim of this study was to evaluate the short- and long-term outcomes in ASA patients with mild hypertrophy (IVS ≤ 16 mm).
Methods And Results: We retrospectively evaluated 1505 consecutive ASA patients and used propensity score to match 172 pairs (344 patients) in groups IVS ≤ 16 mm or IVS > 16 mm.
Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies.
View Article and Find Full Text PDFBackground: Hypertrophic cardiomyopathy (HCM) is caused by mutations in a number of genes. Its prevalence is 0.2% to 0.
View Article and Find Full Text PDFBackground: Alcohol-induced infarction for treatment of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) was discussed as a risk factor for increased cardiac mortality during follow-up.
Objectives: This study sought to report on long-term survival after echo-guided alcohol septal ablation (percutaneous transluminal septal myocardial ablation [PTSMA]) in symptomatic patients with HOCM.
Methods: Between May 2000 and June 2017, PTSMA with alcohol injection was performed in 952 patients (age 55.