Fatigue performance of adhesively cemented glass-, hybrid- and resin-ceramic materials for CAD/CAM monolithic restorations.

Objective: To evaluate the fatigue failure load, number of cycles until failure, and survival probability of adhesively cemented materials with different microstructures (glass-, hybrid- and resin-ceramic) used to manufacture CAD/CAM monolithic restorations.

Methods: Disc-shaped specimens (n=15; Ø=10mm; thickness=1.0mm) were produced from CAD/CAM blocks as follows: feldspathic (FEL); leucite (LEU); lithium disilicate (LD); zirconia-reinforced lithium silicate (ZRLS); polymer-infiltrated ceramic network (PICN); and resin nanoceramic (RNC).

Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep.

Objective: To evaluate the efficacy of levetiracetam (LEV) in continuous spikes and waves during slow sleep (CSWS). Despite first description dates back to 1971, no agreement exists about CSWS treatment. The condition is rare and controlled clinical trials are very difficult to perform, so the reports about efficacy of different drugs are anecdotal.