Publications by authors named "Segal Gad"

Background: Home hospitalization is a care modality growing in popularity worldwide. Telemedicine-driven hospital-at-home (HAH) services could replace traditional hospital departments for selected patients. Chest x-rays typically serve as a key diagnostic tool in such cases.

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  • Israeli medical cadets undergo a crucial 12-month internship that significantly impacts their future, but many experience burnout and feelings of uncertainty.
  • A study in a tertiary hospital implemented personalized psychological and counseling services over 18 months, measuring cadets' satisfaction and socialization before and after the intervention.
  • Results indicated significant improvements in cadets' knowledge acquisition, departmental integration, motivation to recommend the program, and acceptance by staff nurses, suggesting that ongoing support may help reduce burnout.
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The Israeli health system is experiencing an ongoing manpower crisis that will deepen soon with the increase in the number of patients and the overcrowding in clinics and hospitals. The core of the crisis is the need to staff the hospitalization departments and clinics with quality manpower. Alongside the initial staffing, there is an obligation to ensure the survivability of the professional personnel in the system over the years, and this must be done while constantly preventing the process of professional burnout.

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Sarcopenia is characterized by a loss of muscle mass and function and is often associated with frailty, a syndrome linked to physical disability and shortened survival in various patient populations, including cancer patients. Low serum alanine aminotransferase (ALT) values, serving as a biomarker for sarcopenia, were previously associated with frailty and shortened survival in several cancers. In the current study, we aimed to test the association between low ALT and shorter survival in renal cell carcinoma (RCC) patients and survivors.

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Hypothyroidism is very common worldwide. It is known to be associated with frailty which, in turn, is associated with increased morbidity and mortality in the elderly. Low ALT blood activity is an established marker for sarcopenia and frailty.

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Background: Prompt diagnosis of bacteremia in the emergency department (ED) is of utmost importance. Nevertheless, the average time to first clinical laboratory finding range from 1 to 3 days. Alongside a myriad of scoring systems for occult bacteremia prediction, efforts for applying artificial intelligence (AI) in this realm are still preliminary.

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Background: Recruitment to residency programs in hospitals located in other than major hubs ("remotely located") is a challenge in many countries. In 2011, the Israeli Ministry of Health launched a 10-year financial incentive to encourage physicians to enroll in residency programs in such hospitals. Nearly 1 billion New Israeli Shekels (260 million US$) were invested in that program which had only limited success.

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  • Hospital-at-home (HAH) is emerging as a viable alternative to traditional hospital stays for acutely ill patients, allowing care in familiar environments.
  • A study comparing outcomes between HAH and in-hospital treatments showed that HAH patients experienced shorter hospital stays, with significantly lower 30-day mortality rates for both COVID-19 and non-COVID patients.
  • The results indicate that HAH could be a safe option, with no significant increase in readmission rates, suggesting it may effectively manage certain acute illnesses.
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  • Late identification of pulmonary embolism (PE), a serious condition affecting lung arteries, poses significant challenges in healthcare, prompting efforts to improve early diagnosis using existing medical record data.
  • The study developed machine learning models by analyzing data from over 55,000 patients, focusing on demographics and medical history to predict PE risk during hospital admission.
  • The models achieved an 80% accuracy in identifying high-risk patients, revealing specific subgroups with a notably higher prevalence of PE, which can help clinicians better target interventions and improve early detection.
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  • A study was conducted on patients receiving hospital-at-home (HAH) treatment to assess the prevalence and management of electrolyte disturbances, which are not typically included as a primary reason for HAH care.
  • The analysis reviewed data from 267 patients over 14 months, revealing that 97.75% had electrolyte disturbances, with conditions like hyponatremia being the most common.
  • Results indicated that patients with these disturbances had higher rates of chronic kidney disease and cancer, but the treatment in a home setting showed no significant complications, such as death or serious heart issues.
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  • Sarcopenia, marked by loss of muscle mass and function, is linked to frailty and increased risks of falls, fractures, and physical disability, especially in cancer patients.
  • A study analyzed 3,075 bladder cancer patients and found that those with low alanine aminotransferase (ALT) levels, indicating sarcopenia, had significantly lower muscle mass and were older with poorer health metrics.
  • The results suggest that low ALT values are associated with a 22% increased mortality risk in bladder cancer patients, highlighting the importance of monitoring muscle health in cancer care.
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Digital transformation in healthcare during the COVID-19 pandemic led to the development of new hybrid models integrating physical and virtual care. The ability to provide remote care by telemedicine technologies and the need to better manage and control hospitals' occupancy accelerated growth in hospital-at-home programs. The Sheba Medical Center restructured to create Sheba Beyond as the first virtual hospital in Israel.

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Background: The hospital-at-home (HAH) model is a viable alternative for conventional in-hospital stays worldwide. Serum electrolyte abnormalities are common in acute patients, especially in those with many comorbidities. Pathologic changes in cardiac electrophysiology pose a potential risk during HAH stays.

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Background: Technological advancement may bridge gaps between long-practiced medical competencies and modern technologies. Such a domain is the application of digital stethoscopes used for physical examination in telemedicine. This study aimed to validate the level of consensus among physicians regarding the interpretation of remote, digital auscultation of heart and lung sounds.

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Background: Chronic lymphocytic leukemia (CLL) is one of the most common hematologic malignancies, especially among elderlies. Several prognostic scores are available that utilize the characteristics of patients' blood counts and cytogenetic anomalies-all are features of the disease rather than of the patient. Addressing the route of personalized rather than precise medicine, we refer to the assessment of patients' status of sarcopenia and frailty.

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  • Sarcopenia, characterized by loss of muscle mass and function, is linked to frailty and shorter survival rates in cancer patients, with low alanine aminotransferase (ALT) indicating muscle loss.
  • This study retrospectively analyzed prostate cancer (PCa) patients to explore the correlation between low ALT levels and reduced survival.
  • Results showed that low ALT levels (below 17 IU/l) were associated with a significant increase in mortality risk, highlighting the importance of muscle mass in cancer prognosis.
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  • The study investigates the link between low ALT (Alanine-aminotransferase) levels and increased mortality risk in hospitalized COVID-19 patients, given its association with sarcopenia and frailty.
  • Data from 357 patients showed that those with low ALT were more likely to die, with a hazard ratio of 1.82, indicating that low ALT is a significant predictor of worse outcomes.
  • The research concludes that low ALT levels are independently associated with a higher risk of mortality in COVID-19 patients, even after accounting for other risk factors like age and comorbidities.
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Digital transformation of healthcare systems should rely on decentralized computer networks and take advantage of the unique characteristics of blockchain technology. Decentralization ensures process transparency and data transparency for all relevant stakeholders. These values are essential in the realms of populations' healthcare information communications and processing, control and tracking of medical logistics supply chains, clinical research management, and control of certified healthcare services organizations.

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  • * The study aimed to explore the link between low Alanine Aminotransferase (ALT) levels, which indicate muscle mass loss and frailty, and the survival rates of MDS patients, involving 831 individuals in a tertiary hospital setting.
  • * Results showed that low ALT levels were tied to a 25% increase in mortality, even after adjusting for other factors, suggesting that using ALT as a frailty measure could lead to more personalized care for MDS patients.
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  • The study aimed to determine if low complement levels in patients with positive anti-phospholipid antibodies can predict worse health outcomes, focusing on mortality and complications during hospitalization.
  • Researchers examined the medical records of over 6,800 hospitalized patients with abnormal anti-phospholipid antibodies and complement levels between 2007 and 2021, finding that those with low complement levels had significantly higher mortality rates.
  • The results indicate that low complement levels are an independent predictor of higher mortality, aligning with recent findings about the importance of complement activation in anti-phospholipid syndrome.
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Background: The prognosis of long-term clinical outcomes for each patient is of utmost importance.

Objectives: To evaluate the association between rates of family attendance during rounds and long-term outcomes.

Methods: We conducted a historic cohort study.

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  • The study created a machine learning model to help doctors monitor COVID-19 patients in hospitals and spot who might get worse soon.
  • They used real patient data to test how well the model works, focusing on eight blood tests that change before a patient gets more severe.
  • The model showed good accuracy in predicting patient status changes, and if successful in future studies, it could help doctors give better care and manage hospital resources.
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Introduction: Coronavirus disease 2019 (COVID-19) disease is associated with coagulopathy and an increased risk of thrombosis. An association between thrombin generation (TG) capacity, disease severity, and outcomes has not been well described.

Methods: We assessed the correlation of TG with sequential organ failure assessment (SOFA) and sepsis-induced coagulopathy (SIC) scores and clinical outcomes by analysis of plasma samples obtained from hospitalized COVID-19 patients.

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Accurate prediction of mortality upon hospital admission is of great value, both for the sake of patients and appropriate resources' allocation. A myriad of assessment tools exists for this purpose. The evidence relating to the comparative value of clinical assessment versus established indexes are scarce.

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