Evaluation of carbon:nitrogen ratio in semi-defined culture medium to tacrolimus biosynthesis by and the effect on bacterial growth.

Tacrolimus is an immunosuppressant produced by several species, widely used in transplantolgy and dermatology. In this report, attempts have been made to enhance tacrolimus productivity by altering the primary carbon source on culture media. In order to better understand the effects of glucose and maltose on tacrolimus biosynthesis, different carbon contents of these sugars were evaluated in the culture media, thus altering the carbon:nitrogen ratio.