The effects of copper, zinc and bicarbonate in blood, kidney and liver in rats under intermittent hypobaric hypoxia.

Intermittent hypobaric hypoxia is defined as to be below the normal values of partial oxygen pressure at tissue due to hypoxia periods. It can lead to increased reactive oxygen species which causes oxidative damage to DNA, lipids and proteins. The effect of antioxidant defense mechanism varies from tissue to tissue under hypoxic conditions.

The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits.

Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous humor fluid in diabetic and non-diabetic conditions. Therefore, we aimed to investigate zinc (Zn), copper (Cu), and chromium (Cr) levels in plasma and aqueous humor fluids of rabbits in the diabetic rabbit model.

The potential protective roles of zinc, selenium and glutathione on hypoxia-induced TRPM2 channel activation in transfected HEK293 cells.

Hypoxia induces cell death through excessive production of reactive oxygen species (ROS) and calcium (Ca) influx in cells and TRPM2 cation channel is activated by oxidative stress. Zinc (Zn), selenium (Se), and glutathione (GSH) have antioxidant properties in several cells and hypoxia-induced TRPM2 channel activity, ROS and cell death may be inhibited by the Zn, Se, and GSH treatments. We investigated effects of Zn, Se, and GSH on lipid peroxidation (LPO), cell cytotoxicity and death through inhibition of TRPM2 channel activity in transfected HEK293 cells exposed to hypoxia defined as oxygen deficiency.

The relationship of acute myocardial infarction with or without ST-segment elevation and viscosity.

We compared hemorheological parameters in 42 male patients with acute myocardial infarction (AMI), with (n = 22) or without (n = 20) ST-segment elevation and in 20 controls. Plasma and blood viscosity (cP), plasma protein (g/dL) and fibrinogen (mg/dL) concentrations, red (10(6)/µL) and white (10(3)/µL) blood cell counts, hemoglobin concentration (g/dL), and hematocrit (%) were compared. Plasma viscosity was significantly higher in patients with AMI with (P = .

Electrical skin resistance and thermal findings in patients with lumbar disc herniation.

The purpose of this study is to analyze two methods, skin temperature and electrical skin resistance, to evaluate the sympathetic dysfunction in patients with lumbar disc herniation, aiming to determine their accuracy and clinical correlation. Fifteen voluntary patients with lumbar disc herniation were included in this study. Affected dermatome was determined, and skin temperature and electrical skin resistance were recorded from this dermatome and the symmetric healthy dermatome.

Role of +(-)catechin against cadmium toxicity in the rat testes.

Unlabelled: OBJECTIVE; Cadmium (Cd) is one of the most toxic and carcinogenic heavy metals to organisms. Exposure to the metal occurs mainly through environmental pollution and its wide range of uses in industrial fields. Cadmium performs its effect on living organisms by accumulating in various tissues and affecting tissue antioxidant enzyme systems.

Apoptotic rate and metallothionein levels in the tissues of cadmium- and copper-exposed rats.

It is well known that cadmium (Cd) has toxic and carcinogenic effects in rodents and humans, but the effects of Cd on apoptosis are still not clear. Although some studies have shown that Cd has apoptotic potential, other studies have shown that Cd can be antiapoptotic. Parameters such as sensitivity of the exposed organism or cells and the exposure conditions should be important in delineating the effect of Cd on apoptosis.