Design and Synthesis of Novel 5-((3-(Trifluoromethyl)piperidin-1-yl)sulfonyl)indoline-2,3-dione Derivatives as Promising Antiviral Agents: In Vitro, In Silico, and Structure-Activity Relationship Studies.

Herein, a series of new isatin derivatives was designed and synthesized (-) as broad-spectrum antiviral agents. Consequently, the antiviral activities of the synthesized compounds (-) were pursued against three viruses, namely influenza virus (H1N1), herpes simplex virus 1 (HSV-1), and coxsackievirus B3 (COX-B3). In particular, compounds , , and displayed the highest antiviral activity against H1N1, HSV-1, and COX-B3 with IC values of 0.