Comparative Effect of Individual Herbs and Their Combination on Sucrose Tolerance in Normoglycemic Rats and Assessment of Sensory and Nutritional Attributes of Fortified Bread With Polyherbal Formulation.

Introduction: Type 2 diabetes mellitus (T2DM) is a substantial worldwide health issue characterized by chronic hyperglycemia and secondary health complications. The current investigation intends to assess the in vivo hypoglycemic potential of selected medicinal herbs (, , , , , , and ) and their combination and evaluate the sensory and nutritional characteristics of newly fortified bread with polyherbal formulation (PHF).

Methodology: Male Wistar albino rats have been allocated into standard and experimental groups, receiving individual herb crude powder and PHF at different doses, i.

Transition-metal-free decarbonylation-oxidation of 3-arylbenzofuran-2(3)-ones: access to 2-hydroxybenzophenones.

A transition-metal-free decarbonylation-oxidation protocol for the conversion of 3-arylbenzofuran-2(3)-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ-generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields.

N-rich carbon nanosphere as fluorescent nanoprobe for intracellular iron.

Nitrogen rich carbon nanoparticles are known to provide higher fluorescence stokes shift, and thereby are potential candidates for fluorescent sensors. Herein, a facile one-step hydrothermal synthesis is reported for N-rich carbon nanospheres (G-CNS) from caffeine and o-phenylenediamine as precursors. The as-synthesized G-CNS showed high fluorescence with λ at 509 nm, with a highly selective fluorescence turn-off response towards Fe/Fe, rendering these carbon nanospheres as potential candidates to detect intracellular labile iron pool in live cells.

A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12.

A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF], followed by a diastereoselective asymmetric dihydroxylation as the key steps for incorporating the stereogenic centers. The further conversion to the appropriate intermediates and subsequent acylation with lauric acid furnished the target compound.