SAFETY AND THERAPEUTIC EFFECTS OF ORALLY ADMINISTERED AKST4290 IN NEWLY DIAGNOSED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Purpose: To evaluate the safety and therapeutic effects of orally administered AKST4290 (formerly BI 144807 and ALK4290) in treatment-naive patients with neovascular age-related macular degeneration.

Methods: In this prospective, multicenter, open-label Phase 2a pilot clinical study, 30 patients with newly diagnosed neovascular age-related macular degeneration self-administered AKST4290 (400 mg) orally twice daily for 6 weeks. Patients were examined weekly for safety, to measure best-corrected visual acuity (BCVA), and to perform exploratory morphologic assessments.

Mechanistic insight of structural and optical properties of BiOCl in the presence of CNTs and investigating photodegradation of phenol by BiOCl/CNT composites.

In this work, we have synthesized composites of BiOCl with carbon nanotubes (CNTs) a hydrothermal method. Different compositions of CNTs were used to study their influence on the physicochemical properties of BiOCl. Based on the interesting results obtained, various significant correlations were made.

Photocatalytic Degradation of Orange G Dye by Using Bismuth Molybdate: Photocatalysis Optimization and Modeling via Definitive Screening Designs.

In the current study, Bismuth molybdate was synthesized using simple co-precipitation procedure, and their characterization was carried out by various methods such as FT-IR, SEM, and P-XRD. Furthermore, the photocatalytic degradation of Orange G (ORG) dye using synthesized catalyst under visible light irradiation was studied. Response surface Method was used for the optimization of process variables and degradation kinetics evaluated by modeling of experimental data.

Efficient charge separation and improved photocatalytic activity in Type-II & Type-III heterojunction based multiple interfaces in BiOClBr-Q: DFT and Experimental Insight.

The nanostructured, inner-coupled Bismuth oxyhalides (BiOXX'; X, X' = Cl, Br, I; X≠X') heterostructures were prepared using Quercetin (Q) as a sensitizer. The present study revealed the tuning of the band properties of as-prepared catalysts. The catalysts were characterized using various characterization techniques for evaluating the superior photocatalytic efficiency and a better understanding of elemental interactions at interfaces formed in the heterojunction.

Complications of Hair Transplant Procedures-Causes and Management.

Hair transplant surgery per se has low risk, is relatively safe, and has minimum incidence of complications. However, it is a well-accepted fact that no medical science procedure exists without any potential risk of complications. The complication may be a single complaint in the form of pain, itching, dissatisfaction related to the procedure's outcome, or surgical complication in the form of infection, wound dehiscence or skin necrosis.

Overview of Follicular Extraction.

Follicular unit extraction (FUE), now named as follicular unit excision, is one of the methods of harvesting hair follicles from the donor area for implanting in the recipient area. The occipital scalp area is the most common donor area, but nonscalp donor areas like beard, chest, and other hairy body parts can be used as donor hair follicle area. The extraction of the hair follicle leaves a tiny circular scar over the donor area.

Nanotechnology-Based Approach to Combat Pandemic COVID 19: A Review.

The emergence of a novel Corona virus (COVID 19) originated on December 19 from China. The city of Wuhan, the capital city of Hubei province, China, is responsible for an outbreak of respiratory illness known as COVID 19 and it has been rapidly spread across the world claiming millions of lives. The sudden outbreak of novel Coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCoV), is a big concern for their speedy mitigation using the predictable treatment and creating its approach around the world.

COVID-19 transmission: a positive perspective.

Objectives: To understand the dynamics of infectivity of COVID-19 and allay the fear and anxiety associated with it in healthcare workers and the society.

Case Presentation: Three individuals accompanied their pediatric patients in the COVID ward but did not develop infection. Information about their knowledge and perspective about the disease and the protective measures undertaken by them during their stay in the hospital was gathered by administering a questionnaire 14 days after discharge.

The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study.

Objectives: Epilepsy is one of the most common neurological disorders, diagnosis of which is challenging as many unrelated conditions may mimic seizure. Epilepsy impairs the quality of life of patients due to associated physical and psychological trauma. Epileptic patients are also at increased risk of premature death due to autonomic disturbance and fatal accidents.

Evaluation of maternal plasma platelet activating factor acetylhydrolase activity and mRNA expression in pre-eclampsia: a case control study.

Preeclampsia (PE) remains a leading cause of maternal morbidity and mortality all over the world. However, its aetiology and pathophysiology remain elusive. Platelet activating factor (PAF) is produced in response to oxidative stress and is a potent hypotensive agent.

Innovative and Cost-Efficient BiOI Immobilization Technique on Ceramic Paper-Total Coverage and High Photocatalytic Activity.

In the present work, visible light active bismuth oxyiodide (BiOI) was immobilized on a commercial, non-conductive support (an AlO based ceramic paper) using a novel two-step spray coating technique and investigated with different characterization methods (e.g., SEM, Raman, XPS).

"Combination Grafting" of Scalp and Body Hair to Enhance the Visual Density of Hair Transplant and Coverage of Higher Grade of Baldness.

Unlabelled: Hair transplant is becoming the most common cosmetic procedure across the world with demand for higher density and coverage of baldness. This needs more number of donor hair follicles. Scalp donor has limitations to fulfill the required number of follicles for Norwood Grade VI and VII baldness.

Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy, Third Edition.

Contributors The following document and appendices represent the third edition of the . These guidelines were developed by the Diabetic Retinopathy Telehealth Practice Guidelines Working Group. This working group consisted of a large number of subject matter experts in clinical applications for telehealth in ophthalmology.

A Histological and Clinical Evaluation of Plasma as a Graft Holding Solution and Its Efficacy in Terms of Hair Growth and Graft Survival.

 There is a time lag between hair follicle harvesting and implantation, during this time hair follicles suffer ischemic injury. We need a holding medium or a solution to minimize or neutralize ischemic injury.  To evaluate plasma as a graft holding solution in terms of its efficacy in hair growth and hair graft survival.

Fabrication of leaf extract mediated bismuth oxybromide/oxyiodide (BiOBrI) photocatalysts with tunable band gap and enhanced optical absorption for degradation of organic pollutants.

The use of Azadirachta indica (A.I.) leaf extract to synthesize green photocatalysts for efficient separation of photogenerated charges has been a promising way to enhance the photocatalytic activity.

Donor Harvesting: Follicular Unit Excision.

FUE or follicular unit excision is one of the methods for hair follicle harvesting in hair transplantation. FUE involves harvesting hairs from the donor area, under local anesthesia which is most commonly the scalp but occasionally beard, chest and other parts of the body, using a circular punch less than a mm, mounted on a manual handle or a motorized hand device or more recently a robotic device. First hair transplant was done by Dr Shoji Okuda in 1937.

Trends and Racial/Ethnic Disparities in Diabetic Retinopathy Among Adults with Diagnosed Diabetes in North Carolina, 2000-2015.

There is limited information available in North Carolina on the current burden of, and racial disparities in, diabetic retinopathy (DR), a major complication associated with diabetes mellitus (DM). This study aims to describe the overall trend of, and racial/ethnic disparities in, DR among adults with DM in North Carolina. Data were from 13 waves (2000, 2002-2010, 2012, 2013, and 2015) of the Behavioral Risk Factor Surveillance System.

A Histological and Clinical Evaluation of Plasma as a Graft-holding Solution and Its Efficacy in Terms of Hair Growth and Graft Survival.

Background: There is a time lag between hair follicle harvesting and implantation; during this time, hair follicles have ischemic injury. We need a holding media or a solution to minimize or neutralize ischemic injury.

Aim And Objectives: The aim of this study was to evaluate plasma as a graft-holding solution in terms of its efficacy in hair growth and hair graft survival.

Impact of an Individually Tailored Light Mask on Sleep Parameters in Older Adults With Advanced Phase Sleep Disorder.

: This study investigated whether light delivered through the eyelids of sleeping persons might create phase delay in older adults who are adversely affected by advanced sleep phase disorder. : Thirty-two cognitively intact, community-dwelling participants aged ≥ 50 years (20 females, 12 males) with Pittsburgh Sleep Quality Index scores ≥ 5 (poor sleep) completed the study. : This within-subjects, randomized, two-treatment crossover design study exposed participants to an active "blue" (λ  =  480 nm) lighting intervention or a placebo "red" (λ = 640 nm) control through closed eyelids during sleep for 8 weeks.

A Review on BiOX (X= Cl, Br and I) Nano-/Microstructures for Their Photocatalytic Applications.

In the recent past, bismuth oxyhalides (BiOX) have been widely used for the photocatalytic degradation of the organic pollutants and other environmental remediation because of their higher stability, economic viability, nontoxicity and effective charge separation. We begin with the review of the different approaches adopted so far for BiOX (X = Cl, Br, and I) synthesis and a study of their photocatalytic performances under UV and visible light towards the various organic as well as inorganic pollutants. Later on, a study on further enhancement of the efficiency of BiOX under UV and visible light irradiation using recent advancements would be presented.

Plant leaf extracts as photocatalytic activity tailoring agents for BiOCl towards environmental remediation.

The inducement of plant leaf extracts for the synthesis of various nanostructures has intrigued researchers across the earth to explore the mechanisms of biologically active compounds present in the plants. Herein, a green modified hydrolysis route has been employed for the synthesis of bismuth oxychloride i.e.

Biofabricated BiOI with enhanced photocatalytic activity under visible light irradiation.

In the recent past, there has been a large-scale utilization of plant extracts for the synthesis of various photocatalysts. The biofabrication technology eliminates the usage of harmful chemicals and serves as an eco-friendly approach for environmental remediation. Herein, a comparative analysis between bismuth oxyiodide synthesized (neem) leaf extract (BiOI-G) and without leaf extract (BiOI-C) has been envisaged.