Publications by authors named "Seema G Naik"
Article Synopsis
- There is limited knowledge about the risk of central nervous system (CNS) involvement in high-grade B-cell lymphoma, not otherwise specified (HGBL NOS), prompting a study that assessed baseline CNS involvement, recurrence rates, and management strategies in patients treated from 2016 to 2021.
- In the study of 160 adults, 7% exhibited baseline CNS involvement, which was linked to MYC rearrangement and certain sites of involvement, but did not significantly impact overall survival outcomes compared to those without CNS involvement.
- The risk of CNS recurrence within three years was found to be 11%, with patients showing initial CNS involvement facing a much higher risk (48.5%), while various other factors such as blood involvement and
Acute myeloid leukemia (AML) is a devastating blood cancer with poor prognosis. Novel effective treatment is an urgent unmet need. Immunotherapy targeting T cell exhaustion by blocking inhibitory pathways, such as PD-1, is promising in cancer treatment.
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- A study analyzed 160 patients with high-grade B-cell lymphoma (HGBL-NOS), a rare type of lymphoma, showing that it has diverse characteristics with varying gene rearrangements and immunophenotypes among patients.
- Most patients presented with advanced disease and were treated with several chemotherapy regimens, including DA-EPOCH-R and R-CHOP, but there was no significant difference in treatment effectiveness regarding complete response or survival rates.
- Key factors predicting poorer outcomes included poor performance status and high lactate dehydrogenase levels, while improvements in diagnostic and treatment methods are needed to enhance prognosis for HGBL-NOS patients.
The use of CD19 chimeric antigen receptor T-cell (CAR-T) therapy for relapsed/refractory solid organ transplantation (SOT)-related post-transplant lymphoproliferative disorder (PTLD) is not well studied. We conducted a multicentre, retrospective analysis of adults with relapsed/refractory SOT-associated PTLD. Among 22 relapsed/refractory SOT-PTLD patients, the pathology was monomorphic B cell.
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- The study investigates the effects of post-transplant cyclophosphamide (PTCy) on immune reconstitution in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on T cell function and composition.
- Results showed that PTCy significantly delayed T cell reconstitution, increasing regulatory T cells (Tregs) while decreasing naïve T cells, leading to a distinct immune signature compared to those who did not receive PTCy.
- The research also found that the presence of multiple inhibitory receptors on T cells and the persistence of PD-1 on CD8 T cells correlated with worse clinical outcomes, such as disease relapse and graft-versus-host disease (GVHD).