Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model.

Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that EPS reduces neurodegeneration by inhibiting reactive oxygen species (ROS)-induced oxidative injury, mitochondrial membrane damage, apoptosis and tauopathy.

Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive Analysis.

Lung cancer is the leading type of cancer worldwide today. Kinases play a crucial role in mediating the signaling pathways, and it directs to control several necessary cellular processes. Conversely, the deregulation of tyrosine kinases leads to oncogenic conversion, uncontrolled cell proliferation and tumorigenesis.

Trends in the extraction, purification, characterisation and biological activities of polysaccharides from tropical and sub-tropical fruits - A comprehensive review.

Tropical and sub-tropical fruits are tremendous sources of polysaccharides (PSs), which are of great interest in the human welfare system as natural medicines, food and cosmetics. This review paper aims to highlight the recent trends in extraction (conventional and non-conventional), purification and analytic techniques of fruit polysaccharides (FPSs). The chemical structure and biological activities, such as immunomodulatory, anti-cancer, anti-oxidant, anti-inflammatory, anti-viral, anti-coagulant and anti-diabetic effects, of PSs extracted from 53 various fruits were compared and discussed.

Anti-diabetic activity of crude polysaccharide and rhamnose-enriched polysaccharide from G. lithophila on Streptozotocin (STZ)-induced in Wistar rats.

The aim of the present study was to elucidate the anti-diabetic effects of the crude polysaccharide and rhamnose-enriched polysaccharide derived from G. lithophila on streptozotocin (STZ)-induced diabetic Wistar rats. Treatment with crude polysaccharide and rhamnose-enriched polysaccharide showed increases in body weight and pancreatic insulin levels and a decrease in blood glucose levels compared with control diabetic rats.

Multi-elemental concentration in different body parts of Sepiella inermis by inductively coupled plasma mass spectrometry.

The present study examined the accumulation of metal on Sepiella inermis from the Mudasalodai Landing Center, from southeast coastal region of India. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine metals including aluminium, boron, cadmium, cobalt, chromium, copper, iron, manganese, magnesium, nickel, lead and zinc. The results showed that metal concentration in S.

Meta-analysis of functional expression and mutational analysis of c-Met in various cancers.

Comprehensive genomic profiling is expected to revolutionize cancer therapy. c-Met signaling is responsible for tumorigenesis in various cancers. In this prospective, we present the prevalence of c-Met mutations and copy number alterations across various solid tumors.

Nanoparticles from Actinobacteria: A Potential Target to Antimicrobial Therapy.

Nanoparticles have gained significant importance in the past two decades, due to their multifaceted applications in the field of nanomedicine. As our ecosystems and habitats are changing due to global warming, many new diseases are emerging continuously. Treating these costs a lot of money and mostly ends up in failure.

Chemical structure and biological properties of a polysaccharide isolated from .

Herein, a polysaccharide obtained from was fractionated anion-exchange column chromatography and purified using gel permeation column chromatography. The chemical characterization of the polysaccharide indicated that it contained 90.16% total carbohydrate, 0% protein, 12.

Bioremediation of wastewater through a quorum sensing triggered MFC: A sustainable measure for waste to energy concept.

A mission for fast advancement has constrained us to unpredictably tap various natural assets. The reckless utilisation of fossil fuels led unmanageable wastes which have greatly affected our health and environment. Endeavours to address these difficulties have conveyed to the frontal area certain creative natural solutions particularly the utilisation of microbial digestion systems.

Application of marine-derived polysaccharides as immunostimulants in aquaculture: A review of current knowledge and further perspectives.

The use of antibiotics in the feeds of cultivable aquatic animals has been generally practised to reduce infectious diseases as well as to improve the survival and growth. In recent years, many countries ban to aquatic animals due to the use of large amount of antibiotics and chemotherapies, thus alternative novel strategies are need to promote the growth of aquatic animals and control the pathogens. Dietary supplementation of marine-derived polysaccharides (MDPs) is one of the potential substitutes for antibiotics in aquatic animal feeds.

Extraction and characterization of chitin from sea snail Conus inscriptus (Reeve, 1843).

The chitin was extracted from C. inscriptus and the structure was elucidated. The yield of the C.

Sulfated polysaccharide from Sargassum tenerrimum attenuates oxidative stress induced reactive oxygen species production in in vitro and in zebrafish model.

The sulfated polysaccharide (SP) was isolated from the brown alga S. tenerrimum. The chemical composition of SP composed of 57 ± 0.

Isolation and chemical characteristics of rhamnose enriched polysaccharide from Grateloupia lithophila.

The crude polysaccharide was extracted from Grateloupia lithophila through hot-water extraction and deproteinization. Further, fractionated by anion-exchange column using Q-Sepharose and purified by gel-permeation chromatography using Sepharose 4-LB column. The crude and purified polysaccharide contains high carbohydrate (75.

Characterization, antimicrobial and antioxidant property of exopolysaccharide mediated silver nanoparticles synthesized by Streptomyces violaceus MM72.

Green synthesis of silver nanoparticle (SNPs) has gained considerable attention in nano-biotechnology and nano-medicine owing their potency and eco-friendliness. In this, we account the exopolysaccharide and its mediated synthesis of SNPs and their biological activities. Exopolysaccharide of the Streptomyces violaceus composed of total carbohydrate (61.

Mucopolysaccharide from cuttlefish: Purification, chemical characterization and bioactive potential.

The sulfated mucopolysaccharide (GAG) was isolated from S. pharonis and the carbohydrate and protein content was found to be 62.4% and 3.

Evaluation of antioxidant activities and chemical analysis of sulfated chitosan from Sepia prashadi.

The chitin and chitosan of S. prashadi was prepared through demineralization, deproteinzation, deacetylation process and sulfation were carried by chlorosulfonic acid in N,N-dimethylformamide. The sulfate content in chitosan was found to be 18.

Bioactive potential and structural chracterization of sulfated polysaccharide from seaweed (Gracilaria corticata).

The Sulfated polysaccharide was purified through anion-exchange and gel permeation column chromatography. The isolated sulfated polysaccharide from C. corticata contains 84% of carbohydrate, 0% of protein, 19.

Structural characterization and biomedical properties of sulfated polysaccharide from the gladius of Sepioteuthis lessoniana (Lesson, 1831).

Sulfated polysaccharide was extracted from the internal shell (gladius) of Sepioteuthis lessoniana. The sulfated polysaccharide contained 61.3% of carbohydrate, 0.

Antioxidant and anticoagulant activity of sulfated polysaccharide from Gracilaria debilis (Forsskal).

Sulfated polysaccharide was isolated from Gracilaria debilis and purified through gel chromatography and their molecular weight was determined through AGE and PAGE. The total sugars in the crude, fractionated and purified polysaccharide were estimated as 52.65%, 59.

Structural characterization and bioactivities of sulfated polysaccharide from Monostroma oxyspermum.

Sulfated polysaccharide was isolated from Monostroma oxyspermum through hot water extraction, anion-exchange and gel permeation column chromatography. The sulfated polysaccharide contained 92% of carbohydrate, 0% of protein, 7.8% of uronic acid, 22% of ash and 33% of moisture respectively.