Publications by authors named "Sediri K"
The focus of the present investigation was to develop amorphous glassy solutions (AGSs) of BCS Class II and IV drugs using sucrose acetate isobutyrate (SAIB). The drugs studied were rifaximin (RFX), dasatinib (DST), aripiprazole (APZ), dolutegravir (DLT), cyclosporine (CYS), itraconazole (ITZ), tacrolimus (TAC), sirolimus (SRL), aprepitant (APT), and carbamazepine (CBZ). AGSs were prepared by dissolving known quantity of the drug in the SAIB at 120 (TAC and APZ), 140 (CYS) or 150 C (RFX, DST, DLT, ITZ, SRL, APT, and CBZ).
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- - The study focused on enhancing the dissolution of the poorly soluble drug lopinavir (LPV) by creating amorphous solid dispersions (ASDs) using a solvent evaporation method with specific ratios of LPV, Eudragit® E100, and microcrystalline cellulose.
- - Solid-state characterization confirmed that the drug transitioned from crystalline to amorphous form, with only about 3% of crystalline LPV remaining in the ASDs.
- - The ASDs significantly improved drug dissolution rates (60.3-73.5% in 15 minutes compared to <2% for pure LPV) and proved stable against crystallization over a month at high temperatures and humidity.
The focus of the present investigation was to develop a predictive dissolution model for tablets coated with blends of cellulose acetate butyrate (CAB) 171-15 and cellulose acetate phthalate (C-A-P) using the design of experiment and chemometric approaches. Diclofenac sodium was used as a model drug. Coating weight gain (X, 5, 7.
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