Publications by authors named "Sedillot N"
Introduction: First-line oxygenation strategy in patients with acute hypoxaemic respiratory failure consists in standard oxygen or high-flow nasal oxygen therapy. Clinical practice guidelines suggest the use of high-flow nasal oxygen rather than standard oxygen. However, findings remain contradictory with a low level of certainty.
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- The study investigates the impact of socio-economic status on respiratory issues in survivors of ARDS due to COVID-19, finding that 40% of patients were socio-economically deprived.
- After a follow-up of 6 months post-ICU, 80% of the 401 patients showed respiratory issues, but socio-economic status did not significantly affect the prevalence of these complications.
- The results suggest that, regardless of socio-economic background, the majority of ARDS survivors experienced respiratory sequelae, indicating the widespread impact of COVID-19 on lung health.
Background And Objectives: To report the prevalence of acute encephalopathy and outcomes in patients with severe coronavirus disease 2019 (COVID-19) and to identify determinants of 90-day outcomes.
Methods: Data from adults with severe COVID-19 and acute encephalopathy were prospectively collected for patients requiring intensive care unit management in 31 university or university-affiliated intensive care units in 6 countries (France, United States, Colombia, Spain, Mexico, and Brazil) between March and September of 2020. Acute encephalopathy was defined, as recently recommended, as subsyndromal delirium or delirium or as a comatose state in case of severely decreased level of consciousness.
Background: Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to tracheal extubation than T-piece trials, without resulting in a higher risk of reintubation, among patients who have a high risk of extubation failure is unknown.
Methods: In this multicenter, open-label trial, we randomly assigned patients who had a high risk of extubation failure (i.
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- The study examines the effectiveness of high-flow nasal cannula oxygen compared to standard oxygen in reducing mortality and the need for intubation in COVID-19 patients experiencing respiratory failure in ICUs.
- Conducted across 34 ICUs in France, the SOHO-COVID trial involved 711 patients, randomly assigned to receive either high-flow oxygen or standard oxygen.
- Results showed no significant difference in mortality rates at day 28 between the two groups, with 10% mortality for high-flow and 11% for standard oxygen, suggesting both methods are similarly effective.
Background: Stress hyperglycemia can persist during an intensive care unit (ICU) stay and result in prolonged requirement for insulin (PRI). The impact of PRI on ICU patient outcomes is not known. We evaluated the relationship between PRI and Day 90 mortality in ICU patients without previous diabetic treatments.
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- * A new multicentre study, called RECOVIDS, aims to explore how social vulnerability impacts recovery in patients who were hospitalized for ARDS related to COVID-19, incorporating both quantitative measurements and qualitative insights into patient experiences.
- * The study will examine patients admitted to intensive care for severe COVID-19 and track their lung health six months post-discharge, focusing on identifying lung sequelae through various tests and assessing the role of socio-economic status in their rehabilitation process.
Article Synopsis
- Hymenoptera venom anaphylaxis is the leading cause of anaphylaxis, accounting for about 20% of fatal cases in adults, and can occur in patients with undiagnosed mastocytosis.
- The lack of typical mastocytosis skin lesions in allergic patients can lead to missed diagnoses, highlighting the need for better diagnostic strategies.
- Cardiovascular symptoms after an insect sting, without common allergic reactions, may indicate underlying clonal mast cell disorders, necessitating serum tryptase testing in these contexts.
Purpose: Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patient's pre-admission usual glycaemia, could improve outcome.
View Article and Find Full Text PDFBackground: We investigated the impact of the COVID-19 crisis on mental health of professionals working in the intensive care unit (ICU) according to the intensity of the epidemic in France.
Methods: This cross-sectional survey was conducted in 77 French hospitals from April 22 to May 13 2020. All ICU frontline healthcare workers were eligible.
Introduction: In intensive care unit (ICU), the decision of extubation is a critical time because mortality is particularly high in case of reintubation. To reduce that risk, guidelines recommend to systematically perform a spontaneous breathing trial (SBT) before extubation in order to mimic the postextubation physiological conditions. SBT is usually performed with a T-piece disconnecting the patient from the ventilator or with low levels of pressure-support ventilation (PSV).
View Article and Find Full Text PDFPurpose: To report the incidence, risk factors, clinical presentation, and outcome predictors of severe leptospirosis requiring intensive care unit (ICU) admission in a temperate zone.
Methods: LEPTOREA was a retrospective multicentre study conducted in 79 ICUs in metropolitan France. Consecutive adults admitted to the ICU for proven severe leptospirosis from January 2012 to September 2016 were included.
Objective: The objective of the study was to describe a five-step protocol for withholding and withdrawing of life support (WH/WDLS) in an emergency department (ED) for terminally ill patients.
Design And Setting: An observational study was conducted in ED of a general hospital.
Patients: A total of 98 patients were admitted over a 1-year period.