Publications by authors named "Sedighe Kazemi Sheykhshabani"
Article Synopsis
- Hyssopus officinalis (H. officinalis) has been used in traditional medicine to treat seizures, and this study investigated its effectiveness against PTZ-induced seizures in rats.
- The extract showed dose-dependent anti-seizure effects, increasing the seizure threshold, reducing mortality, and enhancing cognitive functions like memory and learning while also influencing GABA receptors.
- Results indicated that H. officinalis extract boosts brain antioxidant capacity, decreases harmful substances, and elevates GABA receptor gene expression, suggesting it may play a significant role in managing epilepsy.
Due to recent advances in the field of small molecule-based drugs, designing an efficient siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell-penetrating TAT peptide, MMP2 enzyme-sensitive moiety, and cetuximab antibodies against the EGF receptor were synthesized, purified and verified on HPLC, TLC, SEM, and DLS analyses. Different cellular and molecular experiments were designed to evaluate the transfection efficiency, targeting properties, and functions, including cytotoxicity assay, resensitization assessments, flow cytometry-based uptake assay, BCRP silencing efficiency, real-time PCR, and western blotting.
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