Cholesterol crystals and the formation of cholesterol gallstones.

To examine the relation of cholesterol crystallization to the formation of gallstones, gallbladder bile was obtained by means of duodenal intubation in 54 patients (eight with asymptomatic gallstones) and from 17 patients undergoing cholecystectomy for cholelithiasis. Hepatic bile was obtained from nine patients with common-duct stones. Bile samples were examined for cholesterol monohydrate crystals and analyzed to determine the percentage of cholesterol saturation.

The prevalence of toxoplasma infection in southern Iran.

To determine the prevalence of infection with Toxoplasma gondii in the Fars Province of Iran, sera from 300 patients hospitalised at the Pahlavi University Medical Centre in Shiraz were tested. There were 157 males and 143 females, with a mean age of 39 years (range 10--80 years). The indirect immunofluorescent antibody technique was used and titres of 1:16 and above were considered positive.

Subclinical infection with mycobacteria in southern Iran.

In 50 non-tuberculous adult patients hospitalized in the Pahlavi University Medical Center skin testing with 5 tuberculin units of purified protein derivative of mammalian Mycobacterium tuberculosis (PPD-M) and equivalent amounts of antigen from Mycobacterium kansasii (PPD-Y) and Mycobacterium Gause (PPD-G), as well as 0.1 ml mumps antigen was carried out. Thirty four per cent, 26 per cent and 12 per cent of the patients had induration greater than 10 mm in diameter to PPD-M, PPD-Y and PPD-G respectively.

The status of tuberculin skin testing at the Pahlavi University Medical Centre.

Thirty-four patients with tuberculosis were skin tested with 5 tuberculin units (TU) of purified protein derivative of Mycobacterium tuberculosis (PPD). PPD supplied by Park Davis and Co., Detroit, Michigan, U.

Cholera: a review.

A case of cholera admitted to the Pahlavi University Medical Centre is presented and the aetiology, pathophysiology, complications and treatment of the disease are reviewed and discussed.

Lack of effect of cholestyramine on the pharmacokinetics of clofibrate in man.

The study was undertaken to determine whether cholestyramine (16 g daily) interfered with clofibrate absorption when the two drugs were given together. Fifteen patients taking 1 g of clofibrate twice daily (for 2 to 416 weeks) participated in the study. Clofibrate (as the acid, p-chlorophenoxyisobutyric acid, CPIB) was quantified by thin-layer and gas-liquid chromatography.

Effects of neomycin on absorption, synthesis, and/or flux of cholesterol in man.

The mode of action of the hypocholesteremic drug neomycin (2 g/day) was studied in four patients. All showed a significant reduction in plasma cholesterol concentrations (mean 25 percent, range 18-31 percent), and in one of three patients with hyperglyceridemia there was a decrease of plasma triglycerides of 26 percent. Cholesterol absorption was measured in three of four patients: there was a marked decrease.

Determination of clofibrate in biological fluids by thin-layer and gas-liquid chromatography.

A specific and sensitive method is described for the detection of clofibrate in biological fluids. The drug is separated from associated fatty acids by thin-layer chromatography and the methyl ester is quantified by gas-liquid chromatography. Recovery is excellent, and any small losses are corrected with an internal recovery standard.