Publications by authors named "Seda Kutlug Agackiran"
Clinical course of pediatric-onset Behçet's Disease in young adulthood.
Rheumatology (Oxford)
November 2024
Article Synopsis
- The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
- Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
- The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
Article Synopsis
- The study investigates the wall thickness of the inferior vena cava (IVC) in patients with Behçet's disease (BD) compared to healthy controls, revealing that BD patients have significantly thicker IVC walls.
- Results showed that IVC wall thickness is associated with mucocutaneous and major organ involvement, indicating a correlation between vascular issues and BD symptoms.
- The findings suggest that venous wall inflammation in BD affects not only lower extremity veins but also larger venous structures like the IVC, pointing to a widespread vascular inflammation in this disease.
Article Synopsis
- A recent study investigated the thickness of the common femoral vein (CFV) in patients with Behçet's Disease (BD) using Doppler ultrasonography in both standing and supine positions.
- The study involved 42 BD patients and 41 healthy controls, finding that CFV thickness was significantly greater in BD patients compared to healthy individuals.
- The research concluded that Doppler US is a reliable, non-invasive method for diagnosing BD and that the patient's position does not influence the CFV wall thickness measurements.
The histopathological data about vascular inflammation in Behçet's disease(BD) mainly comprises patients with arterial involvement. Inflammatory cell infiltration was mainly observed around the vasa vasorum and adventitial layer of the aneurysmatic vessels, and only a few cells were seen in the intimal layer during active arteritis. There is limited data for the histopathology of venous inflammation.
View Article and Find Full Text PDFObjective: Immunosuppressives (IS) are the choice of treatment for major organ involvement in Behçet's disease (BD). In this study, we aimed to investigate the relapse rate and new major organ development in BD under ISs during long-term follow-up.
Methods: The files of 1114 BD patients followed in Marmara University Behçet's Clinic were analyzed retrospectively.
Background: The risk of hepatitis B reactivation in hepatitis B surface antigen-negative phase of hepatitis B virus-infected patients exposed to biologic agents is not clear. We aimed to investigate the reactivation rate in hepatitis B surface antigen-negative phase of hepatitis B virus-infected patients after biologic therapy.
Methods: Patients followed at gastroenterology, rheumatology, and dermatology clinics with a diagnosis of immune-mediated inflam matory diseases were screened.
Objectives: Behçet's disease (BD) is a unique systemic vasculitis mainly involving veins, in contrast to other vasculitides. Prior studies have shown that pulmonary arteries (PAs) have a similar structure to systemic veins. In this study we aimed to assess PA wall thickness by transthoracic echocardiography (TTE) in BD patients compared with healthy controls (HCs) and patients with non-inflammatory pulmonary embolism (NIPE).
View Article and Find Full Text PDFBackground: Behcet's disease (BD) may present with life threating complications including neurological and cardiovascular involvement. Neuro-Behcet's disease (NBD) is one of the most important causes of morbidity and mortality in patients with BD. The aim of the present study is to investigate whether patients with NBD are different than BD patients with other manifestations in terms of subclinical myocardial dysfunction.
View Article and Find Full Text PDF