Publications by authors named "Sechenchogt Harnud"
Article Synopsis
- Cyadox (CYA) is a synthetic antibacterial drug, and the study aimed to investigate its transport, distribution, and potential toxicity in animals.
- The research utilized various methods, including fluorescence and molecular docking, and found that CYA binds to bovine serum albumin (BSA) in the bloodstream, affecting the protein's structure and leading to concentration in the liver while being excreted primarily through urine and feces.
- The study concluded that CYA shows low hepatotoxicity but may influence steroid biosynthesis, providing a basis for future research on its use in food animals.
Cyadox (CYA), a 1,4-dioxide quinoxaline, is a safe and effective antibacterial agent with potential use in food-producing animals. The aim of this study was to compare the pharmacokinetics of CYA (Cy0) and its main metabolites [bisdeoxycyadox (Cy1), 4-desoxycyadox (Cy2), N-(quinoxaline-2-methyl)-cyanide acetyl hydrazine (Cy4), quinoxaline-2-carboxylic acid (Cy6), and 2-hydromethyl-3-hydroxy-quinoxaline (Cy12)] after oral administration at three dosages in pigs, chickens, carps, and rats. The concentration vs.
View Article and Find Full Text PDFCyadox is a new antimicrobial growth-promoting agent for food-producing animals. Studies on radiolabeled compounds enable the use of sensitive radiometric analytical methods and help in the elucidation of metabolic and elimination pathways. In the present study, 6-[H]-cyadox with a high specific activity of 2.
View Article and Find Full Text PDFThe metabolism, distribution, and elimination of cyadox (CYA) is investigated in pigs, chickens, carp, and rats to identify the marker residue and target tissue of CYA in food animals for food safety concerns. Following a single oral gavage of [(3)H]-CYA, the total radioactivity was rapidly excreted, with more than 95% of the dose excreted within 14 days in the four species. Fecal excretion of the total radioactivity was 66.
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