Efficacy and Safety of Stereotactic Radiotherapy in Cushing's Disease: A Single Center Experience.

Objective: To determine the efficacy and safety of stereotactic radiotherapy (RT) in patients with Cushing's disease (CD).

Methods: The study included 38 patients [31 patients who received gamma knife radiosurgery (GKS) and 7 patients who received cyberknife hypofractionated RT (HFRT)] with CD. Hormonal remission was considered if the patient had suppressed cortisol levels after low dose dexamethasone, normal 24-hour urinary free cortisol (UFC), and lack or regression of clinical features.