Intensified Continuous Flow Process for the Scalable Production of Bio-Based Glycerol Carbonate.

A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large-scale production of bio-based glycerol carbonate under flow conditions. The direct carbonation of bio-based glycidol with CO is successfully carried out under intensified flow conditions, with Barton's base as a potent homogeneous organocatalyst. Process metrics for the CO coupling step (for the upstream production, output: 3.

On Demand Flow Platform for the Generation of Anhydrous Dinitrogen Trioxide and Its Further Use in N-Nitrosative Reactions.

Dinitrogen trioxide (N O ) is a powerful and efficient nitrosating agent that comes with an unprecedented atom economy. However, the synthetic application of N O is still underdeveloped mostly due to its inherent instability and the lack of reliable protocols for its preparation. This paper presents an open-source setup and procedure for the on-demand generation of anhydrous N O solution (up to 1 M), which can be further used for reactions under batch and flow conditions.