Publications by authors named "Sebastien Normant"
Article Synopsis
- Human prion diseases are severe neurodegenerative conditions with sporadic, infectious, and genetic forms, with the E200K mutation being a common genetic variant of Creutzfeldt-Jakob disease, which has no existing treatments.
- Researchers created a genetic model using the nematode Caenorhabditis elegans to study the effects of the E200K prion protein mutation on neuronal health and behavior, revealing neurodegeneration and misfolding patterns.
- This model helped identify five existing FDA-approved compounds that could combat the harmful effects of the E200K prion protein, advancing the research in prion disease therapies.
Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters.
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