Acute Appendicitis as a First Presentation of Unimetastatic Gastric Adenocarcinoma.

Appendicitis is one of the most common causes of abdominal surgery emergencies worldwide. Here, we report a case of acute appendicitis as a primary presentation of gastric adenocarcinoma with appendiceal metastasis and no evidence of other lesions. This case can be added to only a few other reported cases, showing a similar situation that can help clarify the spread of gastric adenocarcinoma.

Bowel obstruction by sigmoid strangulation as complication after laparoscopic adjustable gastric banding.

Background: Laparoscopic adjustable gastric banding (LAGB) has been widely performed in the past, however, given its limited weight loss compared to some other procedures, this technique is less often used. Furthermore, a number of complications leading to band removal have been reported in the past few years.

Methods: We present a late acute bowel obstruction by sigmoid strangulation in a female patient with the LAGB performed 15 years ago.

Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy.

Background: Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing immunogenic cell death, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT), have the potential to act synergistically with immunotherapy. For the development of new approaches combining locoregional treatments with immunotherapy, a better understanding of the respective effects of TACE and SIRT on recruitment and activation of immune cells in HCC is needed.

Anterograde jejunojejunal intussusception through the distal anastomosis as complication after Roux-en-Y gastric bypass.

Small bowel intussusception is a rare complication after Roux-en-Y gastric bypass (RYGB) whose incidence tends to increase. This rising could be explained by an increasing bariatric surgery over the last two decades and by a better recognition of this potential complication. We report a case of jejunojejunal intussusception in 33-year-old woman 2 years following a laparoscopic RYGB.

Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control.

Changes in airway calibre have the potential to modify exhaled nitric oxide fraction () values and could hamper how captures changes in asthma control. Here, our objective was to assess whether forced expiratory volume in 1 s (FEV) variations alter the ability of to reflect asthma control., asthma control (Asthma Control Questionnaire (ACQ)) and FEV were measured at least two times in 527 patients during 1819 pairs of visits.

Different patterns of exhaled nitric oxide response to β2-agonists in asthmatic patients according to the site of bronchodilation.

Background: In asthmatic patients undergoing airway challenge, fraction of exhaled nitric oxide (FENO) levels decrease after bronchoconstriction. In contrast, model simulations have predicted both decreased and increased FENO levels after bronchodilation, depending on the site of airway obstruction relief.

Objective: We sought to investigate whether β2-agonists might induce divergent effects on FENO values in asthmatic patients as a result of airway obstruction relief occurring at different lung depths.

FeNO as a predictor of asthma control improvement after starting inhaled steroid treatment.

Introduction: The fraction of NO in exhaled air (FeNO) is a marker of inflammation in asthma. The aim of the present study was to assess, in a real-world setting, whether only high (⩾50 ppb) FeNO levels predict improvement in asthma control when being treated with inhaled corticosteroids (ICS), as suggested by current guidelines on the clinical use of FeNO.

Methods: FeNO and asthma control were assessed in a retrospective observational study in 153 non-smoking, steroid-naïve, adult subjects with asthma with a mean age of 40 years both before and after 6 weeks (median follow-up time) of treatment with 500 μg beclomethasone (median).

Exhaled nitric oxide: a biomarker integrating both lung function and airway inflammation changes.

Background: The increased fraction of exhaled nitric oxide (Feno) values observed in asthmatic patients are thought to reflect increased airway inflammation. However, Feno values can be affected by airway caliber reduction, representing a bias when using Feno values to assess asthma control.

Objective: We sought to determine the effect of changes in both airway caliber and inflammation on Feno values using the allergen challenge model.