[Ga]Ga-PSMA-11 in prostate cancer: a comprehensive review.

Imaging of the prostate-specific membrane antigen (PSMA) has become an important tool for managing patients with recurrent prostate cancer, and one of the most frequently employed radiopharmaceuticals is [Ga]Ga-PSMA-11. Herein, we summarize the preclinical development and the clinical applications of [Ga]Ga-PSMA-11 and present side-by-side comparisons with other radiopharmaceuticals or imaging modalities, in order to assist imagers and clinicians in recommending, performing, and interpreting the results of [Ga]Ga-PSMA-11 PET scans in patients with prostate cancer.

Amyloid PET imaging in cardiac amyloidosis: a pilot study using F-flutemetamol positron emission tomography.

Objective: Cardiac amyloidosis is a rare disease characterized by amyloid heart deposits and is usually a part of systemic amyloidosis, in relation to systemic light chain (AL) and transthyretin (ATTR wild-type or genetic) amyloidosis. Several recent studies suggest a promising role of amyloid PET imaging to image cardiac amyloidosis, and several PET tracers are now available for in vivo detection of amyloid deposits. The aim of this study was to evaluate F-flutemetamol in diagnosing cardiac amyloidosis.

Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation.

We report the unexpected findings of ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased ¹⁸F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-¹⁸F-fluoro-L-dihydroxyphenylalanine, a metabolite of ¹⁸F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models.

FDG PET findings of the brain in sudden blindness caused by bilateral central retinal artery occlusion revealing giant cell arteritis.

We report the case of a 73-year-old woman presenting sudden blindness caused by bilateral simultaneous central retinal artery occlusion revealed by ophthalmoscopy. Temporal artery biopsy confirmed the giant cell arteritis. The patient was treated with a systemic steroid without visual recovery.

Giant postsurgical pseudomeningocele by SPECT/CT cisternography.

We describe a case of a 32-year-old man with a giant pseudomeningocele seen on MRI examination 6 months after spinal surgery. Radionuclide SPECT/CT cisternography performed after intrathecal suboccipital injection of In-DTPA identified the site of cerebral spinal fluid leak at the L4 level, and the patient underwent surgical correction of the dural defect. A repeat MRI examination 8 months later showed no signs of recurrence.