Publications by authors named "Sebastien Debarbieux"
Background: Studies demonstrating the potential utility of reflectance confocal microscopy (RCM) have been performed under experimental conditions.
Objective: To provide an overview of RCM practice in real-life.
Methods: A multicenter, prospective study carried out in 10 university dermatology departments in France.
Article Synopsis
- The Ritux 3 trial showed that rituximab is effective and safe as a first-line treatment for pemphigus, although long-term follow-up data was previously lacking.!* -
- This 7-year follow-up study evaluated the long-term outcomes for patients treated with rituximab alongside prednisone versus those treated with prednisone alone, focusing on disease-free survival and relapse rates.!* -
- Results indicated that 93% of patients in the rituximab group achieved complete remission without corticosteroids, showing significantly higher disease-free survival and lower relapse rates compared to the prednisone-only group.!*
Article Synopsis
- The study evaluated the effectiveness and safety of the drug omalizumab for treating bullous pemphigoid (BP) in patients who did not respond to standard treatments, analyzing data from 100 patients across 18 medical centers in France from 2014 to 2021.
- 77% of patients achieved complete remission (CR), and 9% achieved partial remission, with a median time to CR of approximately 3 months, although 14% experienced relapses within a median follow-up of 12 months.
- Higher baseline levels of anti-BP180-NC16A IgE were linked to better CR outcomes, while other factors like urticarial lesions or eosinophil
Efficacy of imiquimod in the management of lentigo maligna.
J Eur Acad Dermatol Venereol
September 2023
Article Synopsis
- Lentigo maligna (LM) is a skin condition that can develop into melanoma; surgery is typically the preferred treatment, but there is uncertainty about the best excision margins.
- A clinical study tested the effectiveness of imiquimod, an immunomodulator, versus placebo over a month, followed by surgical removal of LM.
- Results showed that while imiquimod significantly reduced the size of LM compared to placebo, there was no significant difference in successful surgical removal between the two groups, indicating its potential as an effective treatment option.
Background: Adverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet.
Objectives: To assess a potential relationship between the occurrence of APO and the serum value of anti-BP180 antibodies at the time of PG diagnosis.
Objectives: The clinical value of cryoglobulinemia (CG) in systemic lupus erythematosus (SLE) is largely unknown. The aim of this retrospective study was to describe the characteristics of CG in SLE, its impact on SLE phenotype, and the features associated with cryoglobulinemic vasculitis (CryoVas) in SLE patients.
Methods: This retrospective study conducted in a French university hospital reviewed the data from 213 SLE patients having been screened for CG between January 2013 and December 2017.
Introduction: The characteristics and the prognostic value of regression in primary melanomas are controversial.
Objectives: To further characterize "hot" and "cold" tumor's stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression.
Methods: A 14-year-collection-based retrospective analysis was carried out on 40 patients with confirmed regressive melanomas.
Objective: To deep sequence the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1γ autoantibody-positive dermatomyositis (DM) as TRIM33 somatic mutations in tumours may trigger this auto-immune disease.
Methods: Next generation sequencing of tumour DNA samples from patients with cancer-associated anti-TIF1γ autoantibody-positive DM. Fourteen tumours from 13 anti-TIF1γ autoantibody-positive DM individuals were sequenced along with two control tumours from non-DM individuals.
We report the case of a 60-year-old woman who underwent 18F-FDG PET/CT to evaluate a metastatic breast carcinoma. Follow-up 18F-FDG PET/CT showed progressive disease with 18F-FDG increased in primary tumor, axillary lymph nodes, and pleural and bone diffuse metastases but also a concomitant uptake in multiples joints. The anatomopathological analysis from skin biopsy revealed a multicentric reticulohistiocytosis, considered paraneoplastic in the context.
View Article and Find Full Text PDFBackground: Teledermoscopy (TDS) improves diagnostic accuracy and decreases the number of unnecessary consultations.
Objectives: To determine the diagnostic concordance in tertiary (dermatologist-to-experts) TDS with histopathology/follow-up-based diagnosis.
Methods: A descriptive retrospective cohort study including 290 requests.
Factors Associated With Short-term Relapse in Patients With Pemphigus Who Receive Rituximab as First-line Therapy: A Post Hoc Analysis of a Randomized Clinical Trial.
JAMA Dermatol
May 2020
Article Synopsis
Scleromyxedema is a rare skin and systemic mucinosis that is usually associated with monoclonal gammopathy (MG). In this French multicenter retrospective study of 33 patients, we investigated the clinical and therapeutic features of MG-associated scleromyxedema. Skin molecular signatures were analyzed using a transcriptomic approach.
View Article and Find Full Text PDFThe Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity-Score (ABSIS) scores have been proposed to provide an objective measure of pemphigus activity. These scores have been evaluated only on already treated patients mainly with mild to moderate activity. The objective was to assess the interrater reliability of ABSIS and PDAI scores and their correlation with other severity markers in a large international study.
View Article and Find Full Text PDFBackground: Subungual squamous cell carcinoma (SSCC) and subungual melanoma (SUM) are rare tumors. Several case reports of association of SSCC with SUM (SSCC-SUM) have been published.
Objective: We sought to document the clinical, dermoscopic, and histologic features in a case series of SSCC-SUMs and describe their relative frequency compared with those of SSCC and SUM.
Background: Subungual squamous cell carcinoma (SSCC) is the most frequent tumor of the nail apparatus. Its diagnosis is often missed or delayed because the clinical presentation is atypical and can mimic other conditions. Accurate diagnosis can only be made by performing an appropriate surgical biopsy, but biopsy is painful and often leaves definitive dystrophic scars.
View Article and Find Full Text PDFImportance: Evidence for the long-term efficacy and safety of anti-tumor necrosis factor α agents (anti-TNF) in treating cutaneous sarcoidosis is lacking.
Objective: To determine the efficacy and safety of anti-TNF in treating cutaneous sarcoidosis in a large observational study.
Design, Setting, And Participants: STAT (Sarcoidosis Treated with Anti-TNF) is a French retrospective and prospective multicenter observational database that receives data from teaching hospitals and referral centers, as well as several pneumology, dermatology, and internal medicine departments.